WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H571076
CAS#: 12750-79-7
Description: A 204 is a polycyclic polyether monocarboxylic acid antibiotic. It is a crystalline isolated from fermentation of strain of Streptomyces albus.
Hodoodo Cat#: H571076
Name: A 204
CAS#: 12750-79-7
Chemical Formula: C49H84O17
Exact Mass: 944.57
Molecular Weight: 945.190
Elemental Analysis: C, 62.27; H, 8.96; O, 28.78
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Synonym: A 204; A204; A-204; Antibiotic A 204; Antibiotic A-204; Antibiotic A204
IUPAC/Chemical Name: 2-(2-hydroxy-6-((2-(5'-(6-hydroxy-4-methoxy-3,5,6-trimethyltetrahydro-2H-pyran-2-yl)octahydro-[2,2'-bifuran]-5-yl)-3,9-dimethoxy-2,4,10-trimethyl-1,6-dioxaspiro[4.5]decan-7-yl)methyl)-5-methoxy-4-((5-methoxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-3,5-dimethyltetrahydro-2H-pyran-2-yl)propanoic acid
InChi Key: RHDSQRNKIIRGBB-UHFFFAOYSA-N
InChi Code: InChI=1S/C49H84O17/c1-24-40(56-13)26(3)47(10,52)65-41(24)35-17-16-33(60-35)34-18-20-37(61-34)46(9)42(57-14)28(5)49(66-46)25(2)36(55-12)22-31(63-49)23-38-45(8,58-15)43(27(4)48(53,64-38)29(6)44(50)51)62-39-21-19-32(54-11)30(7)59-39/h24-43,52-53H,16-23H2,1-15H3,(H,50,51)
SMILES Code: COC1CCC(OC2C(C)C(O)(OC(CC3CC(OC)C(C)C4(O3)OC(C)(C5CCC(O5)C6CCC(O6)C7OC(C)(O)C(C)C(OC)C7C)C(OC)C4C)C2(C)OC)C(C)C(=O)O)OC1C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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| In vitro activity: | |
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The following data is based on the product molecular weight 945.19 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Fitzgerald PR. Efficacy of antibiotics A204 sodium A28695A, and A204np against Coccidia of rabbits. J Protozool. 1976 Feb;23(1):150-4. PubMed PMID: 1271305.
2: Wong DT, Horng JS, Hamill RL, Lardy HA. Effect of a new monocarboxylic acid antibiotic, A204, on the monovalent cation permeability of rat liver mitochondria. Biochem Pharmacol. 1971 Nov;20(11):3169-77. PubMed PMID: 4257133.
3: Worth HM, Meyers DB, Gibson WR, Todd GC. Acute and subacute toxicity of A204. Antimicrob Agents Chemother (Bethesda). 1970;10:357-60. PubMed PMID: 5521356.
4: Todd GC, Meyers DB, Pierce EC, Worth HM. Acute reversible myopathy produced by compound A204. Antimicrob Agents Chemother (Bethesda). 1970;10:361-5. PubMed PMID: 5521357.
5: Meyers DB, Todd GC, Gibson WR. Evidence of depletion of intracellular potassium by A204 in the rat. Antimicrob Agents Chemother (Bethesda). 1970;10:91-4. PubMed PMID: 5521379.
6: Griffing WJ, Todd GC, Pierce EC. Ultrastructural changes in rat skeletal and cardiac muscle induced by A204. Antimicrob Agents Chemother (Bethesda). 1970;10:366-73. PubMed PMID: 5521358.
