WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561275
CAS#: 1219163-50-4
Description: C012 Dihydrochloride is a novel small molecule compound which sensitized BRAF wild-type melanoma cells to vemurafenib. C012 Dihydrochloride significantly reduced melanoma cell viability, with limited toxicity for normal human fibroblasts.
Hodoodo Cat#: H561275
Name: C012 Dihydrochloride
CAS#: 1219163-50-4
Chemical Formula: C23H30Cl2N4O
Exact Mass: 448.18
Molecular Weight: 449.420
Elemental Analysis: C, 61.47; H, 6.73; Cl, 15.78; N, 12.47; O, 3.56
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Synonym: C012 Dihydrochloride; C-012 Dihydrochloride; C 012 Dihydrochloride; C012 2HCl; C 012 2HCl; C-012 2HCl;
IUPAC/Chemical Name: {2-[2-(4-Ethoxy-phenyl)-1,3a,8-triaza-cyclopenta[a]inden-8-yl]-ethyl}-diethyl-amine dihydrochloride
InChi Key: ILZRHCYMKHAQQM-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H28N4O.2ClH/c1-4-25(5-2)15-16-26-21-9-7-8-10-22(21)27-17-20(24-23(26)27)18-11-13-19(14-12-18)28-6-3;;/h7-14,17H,4-6,15-16H2,1-3H3;2*1H
SMILES Code: CCN(CCN1C2=NC(C3=CC=C(OCC)C=C3)=CN2C4=C1C=CC=C4)CC.[H]Cl.[H]Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 449.42 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Sutton SK, Carter DR, Kim P, et al. A novel compound which sensitizes BRAF wild-type melanoma cells to vemurafenib in a TRIM16-dependent manner. Oncotarget. 2016;7(32):52166-52178. doi:10.18632/oncotarget.10700.