WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H571094
CAS#: 62524-99-6
Description: Delprostenate is an analogue of PGF(2alpha), which is the naturally occurring prostaglandin used in medicine to induce labor and as an abortifacient.
Hodoodo Cat#: H571094
Name: Delprostenate
CAS#: 62524-99-6
Chemical Formula: C23H29ClO6
Exact Mass: 436.17
Molecular Weight: 436.930
Elemental Analysis: C, 63.23; H, 6.69; Cl, 8.11; O, 21.97
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Synonym: Delprostenate; A 2774; A2774; A-2774
IUPAC/Chemical Name: 2,5-Heptadienoic acid, 7-(2-(4-(3-chlorophenoxy)-3-hydroxy-1-butenyl)-3,5- dihydroxycyclopentyl)-, methyl ester, (1R-(1-alpha(2E,5Z),2-beta(1E,3R*),3-alpha,5-alpha))-
InChi Key: FNAMRDZHKYQEBA-CIVCTDFYSA-N
InChi Code: InChI=1S/C23H29ClO6/c1-29-23(28)10-5-3-2-4-9-19-20(22(27)14-21(19)26)12-11-17(25)15-30-18-8-6-7-16(24)13-18/h2,4-8,10-13,17,19-22,25-27H,3,9,14-15H2,1H3/b4-2-,10-5+,12-11+/t17?,19-,20-,21+,22-/m1/s1
SMILES Code: O=C(OC)/C=C/C/C=C\C[C@@H]1[C@@H](/C=C/C(O)COC2=CC=CC(Cl)=C2)[C@H](O)C[C@@H]1O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 436.93 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Olivera-Muzante J, Gil J, Fierro S, Menchaca A, Rubianes E. Alternatives to improve a prostaglandin-based protocol for timed artificial insemination in sheep. Theriogenology. 2011 Nov;76(8):1501-7. doi: 10.1016/j.theriogenology.2011.06.020. Epub 2011 Jul 31. PubMed PMID: 21803405.
2: Menchaca A, Pinczak A, Rubianes E. Follicular recruitment and ovulatory response to FSH treatment initiated on day 0 or day 3 postovulation in goats. Theriogenology. 2002 Dec;58(9):1713-21. PubMed PMID: 12472141.
3: Ohnami Y, Kikuchi M, Onuma H. Luteal hypoplasia and induced ovulation in cows. Nihon Juigaku Zasshi. 1986 Oct;48(5):863-71. PubMed PMID: 3537423.
4: Rubianes E, Menchaca A, Carbajal B. Response of the 1-5 day-aged ovine corpus luteum to prostaglandin F2alpha. Anim Reprod Sci. 2003 Sep 15;78(1-2):47-55. PubMed PMID: 12753782.
5: Menchaca A, Miller V, Gil J, Pinczak A, Laca M, Rubianes E. Prostaglandin F2alpha treatment associated with timed artificial insemination in ewes. Reprod Domest Anim. 2004 Oct;39(5):352-5. PubMed PMID: 15367269.
6: Menchaca A, Vilariño M, Crispo M, Pinczak A, Rubianes E. Day 0 protocol: superstimulatory treatment initiated in the absence of a large follicle improves ovarian response and embryo yield in goats. Theriogenology. 2007 Nov;68(8):1111-7. Epub 2007 Sep 21. PubMed PMID: 17889305.
7: Tsutsui T, Kawakami E, Orima H, Yamauchi M, Okubo T, Stabenfeldt GH. Effects of prostaglandin F2 alpha-analogue administration on luteal function, implantation of embryos and maintenance of pregnancy in bitches. Nihon Juigaku Zasshi. 1989 Jun;51(3):496-504. PubMed PMID: 2761141.
8: Vilariño M, Cuadro F, Dos Santos-Neto PC, García-Pintos C, Menchaca A. Time of ovulation and pregnancy outcomes obtained with the prostaglandin-based protocol Synchrovine for FTAI in sheep. Theriogenology. 2017 Mar 1;90:163-168. doi: 10.1016/j.theriogenology.2016.12.003. Epub 2016 Dec 3. PubMed PMID: 28166963.