WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561339
CAS#: Unknown
Description: OV-potentiator-28 is a small molecule potentiator of cancer virotherapy. OV-potentiator-28 significantly enhances virus replication-associated luciferase expression, specifically in tumors.
Hodoodo Cat#: H561339
Name: OV-potentiator-28
CAS#: Unknown
Chemical Formula: C10H14Cl2N2O3
Exact Mass: 280.04
Molecular Weight: 281.130
Elemental Analysis: C, 42.72; H, 5.02; Cl, 25.22; N, 9.96; O, 17.07
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Synonym: OV-potentiator-28; OV potentiator 28; OVpotentiator28;
IUPAC/Chemical Name: 3,4-Dichloro-5-hydroxy-1-(2-morpholinoethyl)-1H-pyrrol-2(5H)-one
InChi Key: ODFQNVLUQFTGEI-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H14Cl2N2O3/c11-7-8(12)10(16)14(9(7)15)2-1-13-3-5-17-6-4-13/h9,15H,1-6H2
SMILES Code: O=C1N(CCN2CCOCC2)C(O)C(Cl)=C1Cl
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 281.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Dornan MH, Krishnan R, Macklin AM, Selman M, El Sayes N, Son HH, Davis C, Chen A, Keillor K, Le PJ, Moi C, Ou P, Pardin C, Canez CR, Le Boeuf F, Bell JC, Smith JC, Diallo JS, Boddy CN. First-in-class small molecule potentiators of cancer virotherapy. Sci Rep. 2016 May 26;6:26786. doi: 10.1038/srep26786. PubMed PMID: 27226390; PubMed Central PMCID: PMC4880900.