RO10-5824
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H530904

CAS#: 189744-46-5

Description: RO10-5824 is a D4-selective partial agonist. RO10-5824 is a potent candidate for the management of cocaine use disorders.


Chemical Structure

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RO10-5824
CAS# 189744-46-5

Theoretical Analysis

Hodoodo Cat#: H530904
Name: RO10-5824
CAS#: 189744-46-5
Chemical Formula: C17H20N4
Exact Mass: 280.17
Molecular Weight: 280.380
Elemental Analysis: C, 72.83; H, 7.19; N, 19.98

Price and Availability

Size Price Availability Quantity
100mg USD 1350 2 Weeks
200mg USD 1850 2 Weeks
500mg USD 2650 2 Weeks
1g USD 3450 2 Weeks
2g USD 4850 2 Weeks
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Synonym: RO10-5824; RO 10-5824; RO-10-5824; RO105824; RO 105824; RO-105824.

IUPAC/Chemical Name: 2-methyl-5-((4-phenyl-5,6-dihydropyridin-1(2H)-yl)methyl)pyrimidin-4-amine

InChi Key: KABDATZAOUSYES-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H20N4/c1-13-19-11-16(17(18)20-13)12-21-9-7-15(8-10-21)14-5-3-2-4-6-14/h2-7,11H,8-10,12H2,1H3,(H2,18,19,20)

SMILES Code: NC1=NC(C)=NC=C1CN2CC=C(C3=CC=CC=C3)CC2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 280.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Bergman J, Rheingold CG. Dopamine D₄ Receptor Antagonists for the Treatment of
Cocaine Use Disorders. CNS Neurol Disord Drug Targets. 2015;14(6):707-15. Review.
PubMed PMID: 26022267.


2: Murai T, Nakako T, Ikeda K, Ikejiri M, Ishiyama T, Taiji M. Lack of dopamine
D4 receptor affinity contributes to the procognitive effect of lurasidone. Behav
Brain Res. 2014 Mar 15;261:26-30. doi: 10.1016/j.bbr.2013.11.036. Epub 2013 Dec
1. PubMed PMID: 24304719.