WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530904
CAS#: 189744-46-5
Description: RO10-5824 is a D4-selective partial agonist. RO10-5824 is a potent candidate for the management of cocaine use disorders.
Hodoodo Cat#: H530904
Name: RO10-5824
CAS#: 189744-46-5
Chemical Formula: C17H20N4
Exact Mass: 280.17
Molecular Weight: 280.380
Elemental Analysis: C, 72.83; H, 7.19; N, 19.98
Synonym: RO10-5824; RO 10-5824; RO-10-5824; RO105824; RO 105824; RO-105824.
IUPAC/Chemical Name: 2-methyl-5-((4-phenyl-5,6-dihydropyridin-1(2H)-yl)methyl)pyrimidin-4-amine
InChi Key: KABDATZAOUSYES-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H20N4/c1-13-19-11-16(17(18)20-13)12-21-9-7-15(8-10-21)14-5-3-2-4-6-14/h2-7,11H,8-10,12H2,1H3,(H2,18,19,20)
SMILES Code: NC1=NC(C)=NC=C1CN2CC=C(C3=CC=CC=C3)CC2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 280.38 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Bergman J, Rheingold CG. Dopamine D₄ Receptor Antagonists for the Treatment of
Cocaine Use Disorders. CNS Neurol Disord Drug Targets. 2015;14(6):707-15. Review.
PubMed PMID: 26022267.
2: Murai T, Nakako T, Ikeda K, Ikejiri M, Ishiyama T, Taiji M. Lack of dopamine
D4 receptor affinity contributes to the procognitive effect of lurasidone. Behav
Brain Res. 2014 Mar 15;261:26-30. doi: 10.1016/j.bbr.2013.11.036. Epub 2013 Dec
1. PubMed PMID: 24304719.