WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561470
CAS#: 41134-88-7
Description: NSC156529 downregulates AKT1 signaling, efficiently decreasing the proliferation of human cancer cells in vitro, and substantially inhibiting the growth of prostate tumor xenografts in vivo.
Hodoodo Cat#: H561470
Name: NSC156529
CAS#: 41134-88-7
Chemical Formula: C28H21ClS2
Exact Mass: 0.00
Molecular Weight: 457.046
Elemental Analysis: C, 73.58; H, 4.63; Cl, 7.76; S, 14.03
Synonym: NSC156529; NSC-156529; NSC 156529;
IUPAC/Chemical Name: 6-Methyl-2-phenyl-10-phenylsulfanyl-1H-anthra[1,9-bc]thiophenium chloride
InChi Key: KLQVNXJBZZWIIV-UHFFFAOYSA-M
InChi Code: InChI=1S/C28H21S2.ClH/c1-19-22-14-8-16-25(29-20-10-4-2-5-11-20)27(22)24-18-30(21-12-6-3-7-13-21)26-17-9-15-23(19)28(24)26;/h2-17H,18H2,1H3;1H/q+1;/p-1
SMILES Code: CC1=C2C=CC=C(SC3=CC=CC=C3)C2=C4C5=C1C=CC=C5[S+](C6=CC=CC=C6)C4.[Cl-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 457.05 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Mäemets-Allas K, Belitškin D, Jaks V. The inhibition of Akt-Pdpk1 interaction efficiently suppresses the growth of murine primary liver tumor cells. Biochem Biophys Res Commun. 2016 May 20;474(1):118-125. doi: 10.1016/j.bbrc.2016.04.082. Epub 2016 Apr 19. PubMed PMID: 27103434.
2: Mäemets-Allas K, Viil J, Jaks V. A Novel Inhibitor of AKT1-PDPK1 Interaction Efficiently Suppresses the Activity of AKT Pathway and Restricts Tumor Growth In Vivo. Mol Cancer Ther. 2015 Nov;14(11):2486-96. doi: 10.1158/1535-7163.MCT-15-0281. Epub 2015 Aug 20. PubMed PMID: 26294745.