WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561497
CAS#: 477-57-6
Description: Isotetrandrine is a cell-permeable PLA2 inhibitor. It can block NMO-IgG binding to AQP4 without affecting the expression and function of AQP4. It can also inhibit NMO-IgG binding to astrocyte AQP4 in NMO patient sera and block NMO-IgG-dependent complement-mediated cytotoxicity.
Hodoodo Cat#: H561497
Name: Isotetrandrine
CAS#: 477-57-6
Chemical Formula: C38H42N2O6
Exact Mass: 622.30
Molecular Weight: 622.760
Elemental Analysis: C, 73.29; H, 6.80; N, 4.50; O, 15.41
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Synonym: Isotetrandrine; (R,S)-Tetrandrine; Isosinomenin A; Isosinomenine A; Isotetrandrine;
IUPAC/Chemical Name: (11S,31R)-16,36,37,54-tetramethoxy-12,32-dimethyl-11,12,13,14,31,32,33,34-octahydro-2,6-dioxa-1(7,1),3(8,1)-diisoquinolina-5(1,3),7(1,4)-dibenzenacyclooctaphane
InChi Key: WVTKBKWTSCPRNU-XZWHSSHBSA-N
InChi Code: InChI=1S/C38H42N2O6/c1-39-15-13-25-20-32(42-4)34-22-28(25)29(39)17-23-7-10-27(11-8-23)45-33-19-24(9-12-31(33)41-3)18-30-36-26(14-16-40(30)2)21-35(43-5)37(44-6)38(36)46-34/h7-12,19-22,29-30H,13-18H2,1-6H3/t29-,30+/m0/s1
SMILES Code: COC1=C(OC)C(OC2=C(OC)C=C(CCN(C)[C@H]3CC4=CC=C(OC5=C(OC)C=CC(C[C@H]6N(C)CC7)=C5)C=C4)C3=C2)=C6C7=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 622.76 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
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