WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H407839
CAS#: 79756-69-7
Description: TPI-1, also known as Tyrosine Phosphatase Inhibitor 1, is a SHP-1 inhibitor. TPI-1 selectively increased SHP-1 phospho-substrates (pLck-pY394, pZap70, and pSlp76) in Jurkat T cells but had little effects on pERK1/2 or pLck-pY505 regulated by phosphatases SHP-2 or CD45, respectively. TPI-1 induced mouse splenic-IFN-gamma(+) cells in vitro, approximately 58-fold more effective than sodium stibogluconate, and increased mouse splenic-pLck-pY394 and -IFN-gamma(+) cells in vivo.
Hodoodo Cat#: H407839
Name: TPI-1
CAS#: 79756-69-7
Chemical Formula: 12H6Cl2O2
Exact Mass: 251.97
Molecular Weight: 253.078
Elemental Analysis: C, 56.95; H, 2.39; Cl, 28.02; O, 12.64
Synonym: TPI-1; TPI 1; TPI1; Tyrosine Phosphatase Inhibitor 1.
IUPAC/Chemical Name: 2-(2,5-dichlorophenyl)-2,5-cyclohexadiene-1,4-dione
InChi Key: ZKHFYORNAYYOTM-UHFFFAOYSA-N
InChi Code: InChI=1S/C12H6Cl2O2/c13-7-1-3-11(14)9(5-7)10-6-8(15)2-4-12(10)16/h1-6H
SMILES Code: O=C1C(C2=CC(Cl)=CC=C2Cl)=CC(C=C1)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
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The following data is based on the product molecular weight 253.08 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Kundu S, Fan K, Cao M, Lindner DJ, Zhao ZJ, Borden E, Yi T. Novel SHP-1
inhibitors tyrosine phosphatase inhibitor-1 and analogs with preclinical
anti-tumor activities as tolerated oral agents. J Immunol. 2010 Jun
1;184(11):6529-36. doi: 10.4049/jimmunol.0903562. Epub 2010 Apr 26. PubMed PMID:
20421638; PubMed Central PMCID: PMC3049920.
