(±)-Necrostatin-2
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Hodoodo CAT#: H530971

CAS#: 852391-15-2 (racemic)

Description: Necrostatin-2, also known as (±)-Necrostatin-2, 7-Cl-O-Nec-1 and Nec-1s, is a racemic mixture that inhibits receptor-interacting protein kinase 1 (RIPK1) autophosphorylation.


Chemical Structure

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(±)-Necrostatin-2
CAS# 852391-15-2 (racemic)

Theoretical Analysis

Hodoodo Cat#: H530971
Name: (±)-Necrostatin-2
CAS#: 852391-15-2 (racemic)
Chemical Formula: C13H12ClN3O2
Exact Mass: 277.06
Molecular Weight: 277.708
Elemental Analysis: C, 56.23; H, 4.36; Cl, 12.77; N, 15.13; O, 11.52

Price and Availability

Size Price Availability Quantity
5mg USD 300 2 Weeks
10mg USD 500 2 Weeks
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Related CAS #: 852391-19-6 (R-isomer)   852391-15-2 (racemic)    

Synonym: Necrostatin-2; (±)-Necrostatin-2; 7-Cl-O-Nec-1; Nec-1s;

IUPAC/Chemical Name: 5-[(7-chloro-1H-indol-3-yl)methyl]-3-methyl-2,4-imidazolidinedione

InChi Key: WIKGAEMMNQTUGL-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H12ClN3O2/c1-17-12(18)10(16-13(17)19)5-7-6-15-11-8(7)3-2-4-9(11)14/h2-4,6,10,15H,5H2,1H3,(H,16,19)

SMILES Code: O=C1N(C)C(C(CC2=CNC3=C2C=CC=C3Cl)N1)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 277.71 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Wang Q, Zhou T, Liu Z, Ren J, Phan N, Gupta K, Stewart DM, Morgan S, Assa C,
Kent KC, Liu B. Inhibition of Receptor-Interacting Protein Kinase 1 with
Necrostatin-1s ameliorates disease progression in elastase-induced mouse
abdominal aortic aneurysm model. Sci Rep. 2017 Feb 10;7:42159. doi:
10.1038/srep42159. PubMed PMID: 28186202; PubMed Central PMCID: PMC5301478.


2: Huang Z, Epperly M, Watkins SC, Greenberger JS, Kagan VE, Bayır H.
Necrostatin-1 rescues mice from lethal irradiation. Biochim Biophys Acta. 2016
Apr;1862(4):850-856. doi: 10.1016/j.bbadis.2016.01.014. Epub 2016 Jan 20. PubMed
PMID: 26802452; PubMed Central PMCID: PMC4788560.


3: Berger SB, Harris P, Nagilla R, Kasparcova V, Hoffman S, Swift B, Dare L,
Schaeffer M, Capriotti C, Ouellette M, King BW, Wisnoski D, Cox J, Reilly M,
Marquis RW, Bertin J, Gough PJ. Characterization of GSK'963: a structurally
distinct, potent and selective inhibitor of RIP1 kinase. Cell Death Discov. 2015
Jul 27;1:15009. doi: 10.1038/cddiscovery.2015.9. eCollection 2015. PubMed PMID:
27551444; PubMed Central PMCID: PMC4979471.