DCLX069

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H407843

CAS#: 792946-69-1

Description: DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 effectively blocked cell proliferation in breast cancer, liver cancer and acute myeloid leukemia cell lines. The binding mode analysis from molecular docking simulations theoretically indicated that DCLX069 occupied the SAM binding pocket to exert the inhibitory effect. Protein arginine methylation is a common post-translational modification which is crucial for a variety of biological processes. Dysregulation of protein arginine methyltransferases (PRMTs) activity has been implicated in cancer and other serious diseases.


Chemical Structure

img
DCLX069
CAS# 792946-69-1

Theoretical Analysis

Hodoodo Cat#: H407843
Name: DCLX069
CAS#: 792946-69-1
Chemical Formula: C20H25N3O2
Exact Mass: 339.19
Molecular Weight: 339.439
Elemental Analysis: C, 70.77; H, 7.42; N, 12.38; O, 9.43

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: DCLX069; DCLX-069; DCLX 069.

IUPAC/Chemical Name: Ethyl 3-amino-4-(4-benzyl-1-piperazinyl)benzoate

InChi Key: RITRCMIWRZBDID-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H25N3O2/c1-2-25-20(24)17-8-9-19(18(21)14-17)23-12-10-22(11-13-23)15-16-6-4-3-5-7-16/h3-9,14H,2,10-13,15,21H2,1H3

SMILES Code: O=C(OCC)C1=CC=C(N2CCN(CC3=CC=CC=C3)CC2)C(N)=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 339.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Xie Y, Zhou R, Lian F, Liu Y, Chen L, Shi Z, Zhang N, Zheng M, Shen B, Jiang
H, Liang Z, Luo C. Virtual screening and biological evaluation of novel small
molecular inhibitors against protein arginine methyltransferase 1 (PRMT1). Org
Biomol Chem. 2014 Dec 21;12(47):9665-73. doi: 10.1039/c4ob01591f. Epub 2014 Oct
28. PubMed PMID: 25348815.