WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H407843
CAS#: 792946-69-1
Description: DCLX069 is a potent and selective PRMT1 inhibitor. DCLX069 effectively blocked cell proliferation in breast cancer, liver cancer and acute myeloid leukemia cell lines. The binding mode analysis from molecular docking simulations theoretically indicated that DCLX069 occupied the SAM binding pocket to exert the inhibitory effect. Protein arginine methylation is a common post-translational modification which is crucial for a variety of biological processes. Dysregulation of protein arginine methyltransferases (PRMTs) activity has been implicated in cancer and other serious diseases.
Hodoodo Cat#: H407843
Name: DCLX069
CAS#: 792946-69-1
Chemical Formula: C20H25N3O2
Exact Mass: 339.19
Molecular Weight: 339.439
Elemental Analysis: C, 70.77; H, 7.42; N, 12.38; O, 9.43
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: DCLX069; DCLX-069; DCLX 069.
IUPAC/Chemical Name: Ethyl 3-amino-4-(4-benzyl-1-piperazinyl)benzoate
InChi Key: RITRCMIWRZBDID-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H25N3O2/c1-2-25-20(24)17-8-9-19(18(21)14-17)23-12-10-22(11-13-23)15-16-6-4-3-5-7-16/h3-9,14H,2,10-13,15,21H2,1H3
SMILES Code: O=C(OCC)C1=CC=C(N2CCN(CC3=CC=CC=C3)CC2)C(N)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 339.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Xie Y, Zhou R, Lian F, Liu Y, Chen L, Shi Z, Zhang N, Zheng M, Shen B, Jiang
H, Liang Z, Luo C. Virtual screening and biological evaluation of novel small
molecular inhibitors against protein arginine methyltransferase 1 (PRMT1). Org
Biomol Chem. 2014 Dec 21;12(47):9665-73. doi: 10.1039/c4ob01591f. Epub 2014 Oct
28. PubMed PMID: 25348815.