AF38469
featured

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H571368

CAS#: 1531634-31-7

Description: AF38469 is a novel, selective, orally bioavailable Sortilin inhibitor.

Chemical Structure

img
AF38469
CAS# 1531634-31-7
Instruction

Theoretical Analysis

Hodoodo Cat#: H571368
Name: AF38469
CAS#: 1531634-31-7
Chemical Formula: C15H11F3N2O3
Exact Mass: 324.07
Molecular Weight: 324.260
Elemental Analysis: C, 55.56; H, 3.42; F, 17.58; N, 8.64; O, 14.80

Price and Availability

Size Price Availability Quantity
5mg USD 420 2 Weeks
10mg USD 770 2 Weeks
25mg USD 1350 2 Weeks
Bulk inquiry

Synonym: AF38469; AF 38469; AF-38469

IUPAC/Chemical Name: Benzoic acid, 2-[[(6-methyl-2-pyridinyl)amino]carbonyl]-5-(trifluoromethyl)-

InChi Key: JWCUSQCZMQIBMR-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H11F3N2O3/c1-8-3-2-4-12(19-8)20-13(21)10-6-5-9(15(16,17)18)7-11(10)14(22)23/h2-7H,1H3,(H,22,23)(H,19,20,21)

SMILES Code: O=C(O)C1=CC(C(F)(F)F)=CC=C1C(NC2=NC(C)=CC=C2)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 324.26 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.
=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and SDS / CoA (available online).

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Dilution Calculator

Calculate the dilution required to prepare a stock solution.
x
=
x

1: Schrøder TJ, Christensen S, Lindberg S, Langgård M, David L, Maltas PJ, Eskildsen J, Jacobsen J, Tagmose L, Simonsen KB, Biilmann Rønn LC, de Jong IE, Malik IJ, Karlsson JJ, Bundgaard C, Egebjerg J, Stavenhagen JB, Strandbygård D, Thirup S, Andersen JL, Uppalanchi S, Pervaram S, Kasturi SP, Eradi P, Sakumudi DR, Watson SP. The identification of AF38469: an orally bioavailable inhibitor of the VPS10P family sorting receptor Sortilin. Bioorg Med Chem Lett. 2014 Jan 1;24(1):177-80. doi: 10.1016/j.bmcl.2013.11.046. Epub 2013 Nov 27. PubMed PMID: 24355129.