Thifluzamide
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H561570

CAS#: 130000-40-7

Description: Thifluzamide is a succinate dehydrogenase inhibitor (SDHI) with strong antifungal activity.


Chemical Structure

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Thifluzamide
CAS# 130000-40-7

Theoretical Analysis

Hodoodo Cat#: H561570
Name: Thifluzamide
CAS#: 130000-40-7
Chemical Formula: C13H6Br2F6N2O2S
Exact Mass: 525.84
Molecular Weight: 528.060
Elemental Analysis: C, 29.57; H, 1.15; Br, 30.26; F, 21.59; N, 5.31; O, 6.06; S, 6.07

Price and Availability

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250mg USD 280
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Synonym: Thifluzamide;

IUPAC/Chemical Name: N-(2,6-Dibromo-4-(trifluoromethoxy)phenyl)-2-methyl-4-(trifluoromethyl)thiazole-5-carboxamide

InChi Key: WOSNCVAPUOFXEH-UHFFFAOYSA-N

InChi Code: InChI=1S/C13H6Br2F6N2O2S/c1-4-22-10(12(16,17)18)9(26-4)11(24)23-8-6(14)2-5(3-7(8)15)25-13(19,20)21/h2-3H,1H3,(H,23,24)

SMILES Code: O=C(C1=C(C(F)(F)F)N=C(C)S1)NC2=C(Br)C=C(OC(F)(F)F)C=C2Br

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 528.06 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yao TT, Xiao DX, Li ZS, Cheng JL, Fang SW, Du YJ, Zhao JH, Dong XW, Zhu GN. Design, Synthesis, and Fungicidal Evaluation of Novel Pyrazole-furan and Pyrazole-pyrrole Carboxamide as Succinate Dehydrogenase Inhibitors. J Agric Food Chem. 2017 Jul 5;65(26):5397-5403. doi: 10.1021/acs.jafc.7b01251. Epub 2017 Jun 26. PubMed PMID: 28616975.

2: Yang Y, Liu W, Li D, Qian L, Fu B, Wang C. Altered glycometabolism in zebrafish exposed to thifluzamide. Chemosphere. 2017 Sep;183:89-96. doi: 10.1016/j.chemosphere.2017.05.055. Epub 2017 May 10. PubMed PMID: 28535465.

3: Yao TT, Fang SW, Li ZS, Xiao DX, Cheng JL, Ying HZ, Du YJ, Zhao JH, Dong XW. Discovery of Novel Succinate Dehydrogenase Inhibitors by the Integration of in Silico Library Design and Pharmacophore Mapping. J Agric Food Chem. 2017 Apr 19;65(15):3204-3211. doi: 10.1021/acs.jafc.7b00249. Epub 2017 Apr 5. PubMed PMID: 28358187.

4: Xiong L, Li H, Jiang LN, Ge JM, Yang WC, Zhu XL, Yang GF. Structure-Based Discovery of Potential Fungicides as Succinate Ubiquinone Oxidoreductase Inhibitors. J Agric Food Chem. 2017 Feb 8;65(5):1021-1029. doi: 10.1021/acs.jafc.6b05134. Epub 2017 Jan 31. PubMed PMID: 28110534.

5: Yang Y, Liu W, Mu X, Qi S, Fu B, Wang C. Biological response of zebrafish embryos after short-term exposure to thifluzamide. Sci Rep. 2016 Dec 7;6:38485. doi: 10.1038/srep38485. PubMed PMID: 27924917; PubMed Central PMCID: PMC5141451.

6: Sun HY, Lu CQ, Li W, Deng YY, Chen HG. Homozygous and heterozygous point mutations in succinate dehydrogenase subunits b, c and d of Rhizoctonia cerealis conferring resistance to thifluzamide. Pest Manag Sci. 2017 May;73(5):896-903. doi: 10.1002/ps.4361. Epub 2016 Aug 31. PubMed PMID: 27415408.

7: Ma L, Chen J, Zhao L, Zhan X. [Determination of six amide pesticide residues in vegetables and fruits by solid phase extraction-ultra high performance liquid chromatography-tandem mass spectrometry]. Se Pu. 2015 Oct;33(10):1019-25. Chinese. PubMed PMID: 26930957.

8: Yang Y, Qi S, Wang D, Wang K, Zhu L, Chai T, Wang C. Toxic effects of thifluzamide on zebrafish (Danio rerio). J Hazard Mater. 2016 Apr 15;307:127-36. doi: 10.1016/j.jhazmat.2015.12.055. Epub 2016 Jan 2. PubMed PMID: 26780700.

9: Zhang Y, Lu J, Wang J, Zhou M, Chen C. Baseline sensitivity and resistance risk assessmemt of Rhizoctonia cerealis to thifluzamide, a succinate dehydrogenase inhibitor. Pestic Biochem Physiol. 2015 Oct;124:97-102. doi: 10.1016/j.pestbp.2015.05.004. Epub 2015 May 28. PubMed PMID: 26453237.

10: Gupta S, Gajbhiye VT. Adsorption-desorption, persistence and leaching behavior of thifluzamide in alluvial soil. Chemosphere. 2004 Nov;57(6):471-80. PubMed PMID: 15350409.