Tetracaine
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H561584

CAS#: 94-24-6

Description: Tetracaine is a potent local anesthetic. It alters the function of calcium release channels (ryanodine receptors) that control the release of calcium from intracellular stores.

Chemical Structure

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Tetracaine
CAS# 94-24-6
Instruction

Theoretical Analysis

Hodoodo Cat#: H561584
Name: Tetracaine
CAS#: 94-24-6
Chemical Formula: C15H24N2O2
Exact Mass: 264.18
Molecular Weight: 264.360
Elemental Analysis: C, 68.15; H, 9.15; N, 10.60; O, 12.10

Price and Availability

Size Price Availability Quantity
5g USD 195
25g USD 380
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Synonym: Tetracaine; Amethocaine; Pontocaine; Dicaine; Niphanoid;

IUPAC/Chemical Name: 2-(Dimethylamino)ethyl 4-(butylamino)benzoate

InChi Key: GKCBAIGFKIBETG-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H24N2O2/c1-4-5-10-16-14-8-6-13(7-9-14)15(18)19-12-11-17(2)3/h6-9,16H,4-5,10-12H2,1-3H3

SMILES Code: O=C(OCCN(C)C)C1=CC=C(NCCCC)C=C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 264.36 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Tayeb BO, Eidelman A, Eidelman CL, McNicol ED, Carr DB. Topical anaesthetics for pain control during repair of dermal laceration. Cochrane Database Syst Rev. 2017 Feb 22;2:CD005364. doi: 10.1002/14651858.CD005364.pub3. Review. PubMed PMID: 28230244.

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8: Swaminathan A, Otterness K, Milne K, Rezaie S. The Safety of Topical Anesthetics in the Treatment of Corneal Abrasions: A Review. J Emerg Med. 2015 Nov;49(5):810-5. doi: 10.1016/j.jemermed.2015.06.069. Epub 2015 Aug 15. Review. PubMed PMID: 26281814.

9: Pywell A, Xyrichis A. Does topical Amethocaine cream increase first-time successful cannulation in children compared with a eutectic mixture of local anaesthetics (EMLA) cream? A systematic review and meta-analysis of randomised controlled trials. Emerg Med J. 2015 Sep;32(9):733-7. doi: 10.1136/emermed-2014-204066. Epub 2014 Oct 28. Review. PubMed PMID: 25351196.

10: Faktorovich EG, Melwani K. Efficacy and safety of pain relief medications after photorefractive keratectomy: review of prospective randomized trials. J Cataract Refract Surg. 2014 Oct;40(10):1716-30. doi: 10.1016/j.jcrs.2014.08.001. Review. PubMed PMID: 25263042.

11: Lander JA, Weltman BJ, So SS. WITHDRAWN: EMLA and Amethocaine for reduction of children's pain associated with needle insertion. Cochrane Database Syst Rev. 2014 Mar 13;(3):CD004236. doi: 10.1002/14651858.CD004236.pub3. Review. PubMed PMID: 24627224.

12: Kakinohana M. Protective effects of anesthetics on the spinal cord. Curr Pharm Des. 2014;20(36):5744-50. Review. PubMed PMID: 24502573.

13: Cohen JL. Pain management with a topical lidocaine and tetracaine 7%/7% cream with laser dermatologic procedures. J Drugs Dermatol. 2013 Sep;12(9):986-9. Review. PubMed PMID: 24002144.

14: Khan R, Kuppaswamy BS. Cetacaine induced methemoglobinemia: overview of analysis and treatment strategies. W V Med J. 2013 May-Jun;109(3):24-6. Review. PubMed PMID: 23798277.

15: Wood DN, Nakas N, Gregory CW. Clinical trials assessing ototopical agents in the treatment of pain associated with acute otitis media in children. Int J Pediatr Otorhinolaryngol. 2012 Sep;76(9):1229-35. doi: 10.1016/j.ijporl.2012.05.022. Epub 2012 Jun 25. Review. PubMed PMID: 22739231.

16: Anderson K. Towards evidence-based emergency medicine: best BETs from the Manchester Royal Infirmary. BET 1: Comparison of topical anaesthetic agents for minor wound closure in children. Emerg Med J. 2012 Apr;29(4):339-40. doi: 10.1136/emermed-2012-201159.2. Review. PubMed PMID: 22420000.

17: Mokhtari B, Pourabdollah K. Applications of nano-baskets in drug development: high solubility and low toxicity. Drug Chem Toxicol. 2013 Jan;36(1):119-32. doi: 10.3109/01480545.2011.653490. Epub 2012 Feb 24. Review. PubMed PMID: 22360609.

18: López T, Sánchez FJ, Garzón JC, Muriel C. Spinal anesthesia in pediatric patients. Minerva Anestesiol. 2012 Jan;78(1):78-87. doi: 10.1111/j.1460-9592.2011.03769.x. Epub 2011 Dec 28. Review. PubMed PMID: 22211775.

19: Eidelman A, Weiss JM, Baldwin CL, Enu IK, McNicol ED, Carr DB. Topical anaesthetics for repair of dermal laceration. Cochrane Database Syst Rev. 2011 Jun 15;(6):CD005364. doi: 10.1002/14651858.CD005364.pub2. Review. Update in: Cochrane Database Syst Rev. 2017 Feb 22;2:CD005364. PubMed PMID: 21678347.

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