WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H530991
CAS#: 1243184-62-4
Description: MDK-4624, also known as AMPKα1 activator C13, is a AMPKα1 activator. MDK-4624 has CAS#1243184-62-4. MDK-4624 attenuates dexamethasone-induced osteoblast cell death. MDK-4624 inhibits Helicobacter pylori-induced oxidative stresses and gastric epithelial cell apoptosis. MDK-4624 potently inhibits melanoma cell proliferation.
Hodoodo Cat#: H530991
Name: MDK-4624
CAS#: 1243184-62-4
Chemical Formula: C17H22NO10P
Exact Mass: 431.10
Molecular Weight: 431.334
Elemental Analysis: C, 47.34; H, 5.14; N, 3.25; O, 37.09; P, 7.18
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Synonym: MDK-4624; MDK4624; MDK 4624; AMPKα1 activator C13; C13, Compound 13.
IUPAC/Chemical Name: (((5-(5-oxo-4,5-dihydroisoxazol-3-yl)furan-2-yl)phosphoryl)bis(oxy))bis(methylene) bis(2-methylpropanoate)
InChi Key: NNMZZIPZHAKTQH-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H22NO10P/c1-10(2)16(20)23-8-25-29(22,26-9-24-17(21)11(3)4)15-6-5-13(27-15)12-7-14(19)28-18-12/h5-6,10-11H,7-9H2,1-4H3
SMILES Code: CC(C)C(OCOP(C1=CC=C(C(C2)=NOC2=O)O1)(OCOC(C(C)C)=O)=O)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 431.33 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Zhou C, Gu J, Zhang G, Dong D, Yang Q, Chen MB, Xu D. AMPK-autophagy
inhibition sensitizes icaritin-induced anti-colorectal cancer cell activity.
Oncotarget. 2017 Feb 28;8(9):14736-14747. doi: 10.18632/oncotarget.14718. PubMed
PMID: 28103582; PubMed Central PMCID: PMC5362439.
2: Guo S, Mao L, Ji F, Wang S, Xie Y, Fei H, Wang XD. Activating AMP-activated
protein kinase by an α1 selective activator compound 13 attenuates
dexamethasone-induced osteoblast cell death. Biochem Biophys Res Commun. 2016 Mar
18;471(4):545-52. doi: 10.1016/j.bbrc.2016.02.036. Epub 2016 Feb 15. PubMed PMID:
26891866.
3: Hu X, Jiang F, Bao Q, Qian H, Fang Q, Shao Z. Compound 13, an α1-selective
small molecule activator of AMPK, potently inhibits melanoma cell proliferation.
Tumour Biol. 2016 Jan;37(1):1071-8. doi: 10.1007/s13277-015-3854-8. Epub 2015 Aug
14. PubMed PMID: 26271666.
4: Zhao H, Zhu H, Lin Z, Lin G, Lv G. Compound 13, an α1-selective small molecule
activator of AMPK, inhibits Helicobacter pylori-induced oxidative stresses and
gastric epithelial cell apoptosis. Biochem Biophys Res Commun. 2015 Aug
7;463(4):510-7. doi: 10.1016/j.bbrc.2015.05.059. Epub 2015 May 27. PubMed PMID:
26022128.