WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584113
CAS#: 103051-26-9
Description: B 746 is an antibacterial agent primarily used in therapy for leprosy and Mycobacterium avium infections as well as against Mycobacterium tuberculosis, including those with multi-drug resistance.
Hodoodo Cat#: H584113
Name: B 746
CAS#: 103051-26-9
Chemical Formula: C26H20Cl2N4
Exact Mass: 458.11
Molecular Weight: 459.370
Elemental Analysis: C, 67.98; H, 4.39; Cl, 15.43; N, 12.20
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Synonym: B 746; B-746; B746
IUPAC/Chemical Name: Phenazine, 3-p-chloroanilino-10-(p-chlorophenyl)-2-(ethylimino)-2,10-dihydro-
InChi Key: BYKKMDXGWCEUAY-QUPMIFSKSA-N
InChi Code: InChI=1S/C26H20Cl2N4/c1-2-29-22-16-26-24(15-23(22)30-19-11-7-17(27)8-12-19)31-21-5-3-4-6-25(21)32(26)20-13-9-18(28)10-14-20/h3-16,30H,2H2,1H3/b29-22+
SMILES Code: CC/N=C1C=C2N(C3=CC=C(Cl)C=C3)C4=C(C=CC=C4)N=C2C=C\1NC5=CC=C(Cl)C=C5
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 459.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Jagannath C, Reddy MV, Kailasam S, O'Sullivan JF, Gangadharam PR. Chemotherapeutic activity of clofazimine and its analogues against Mycobacterium tuberculosis. In vitro, intracellular, and in vivo studies. Am J Respir Crit Care Med. 1995 Apr;151(4):1083-6. PubMed PMID: 7697235.
2: Gangadharam PR, Ashtekar D, O'Sullivan JF. In vitro, in vivo, and intracellular chemotherapeutic activity of B746, a clofazimine analogue against Mycobacterium avium complex. Tuber Lung Dis. 1992 Aug;73(4):192-9. PubMed PMID: 1477384.