WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584116
CAS#: 77-46-3
Description: Acedapsone, also known as Acetamin, Atilon, Camilan, and Rodilone, is slowly metabolized to give long-term, low blood levels of DAPSONE. It has antimicrobial and antimalarial action, but is mainly used as a depot leprostatic agent
Hodoodo Cat#: H584116
Name: Acedapsone
CAS#: 77-46-3
Chemical Formula: C16H16N2O4S
Exact Mass: 332.08
Molecular Weight: 332.370
Elemental Analysis: C, 57.82; H, 4.85; N, 8.43; O, 19.25; S, 9.65
This product is not in stock, which may be available by custom synthesis.
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Synonym: Acedapsone; Acetamin; Atilon; Camilan; Rodilon; BA 2650; BA-2650; BA2650
IUPAC/Chemical Name: N,N'-Diacetyl-4,4'-diaminodiphenylsulfone
InChi Key: AMTPYFGPPVFBBI-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H16N2O4S/c1-11(19)17-13-3-7-15(8-4-13)23(21,22)16-9-5-14(6-10-16)18-12(2)20/h3-10H,1-2H3,(H,17,19)(H,18,20)
SMILES Code: O=S(C1=CC=C(NC(C)=O)C=C1)(C2=CC=C(NC(C)=O)C=C2)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 332.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Olivares Sabournin R, González Segredo AB. [Bacteriologic study in patients with multibacillary leprosy treated with rifampicin and acedapsone]. Rev Cubana Med Trop. 1989 May-Aug;41(2):307-12. Spanish. PubMed PMID: 2486227.
2: George J, Balakrishnan S. Blood dapsone levels in leprosy patients treated with acedapsone. Indian J Lepr. 1986 Jul-Sep;58(3):401-6. PubMed PMID: 3794408.
3: Neelan PN, Sirumban P, Sivaprasad N. Limited duration acedapsone prophylaxis in leprosy. Indian J Lepr. 1986 Apr-Jun;58(2):251-6. PubMed PMID: 3543161.
4: Russell DA, Worth RM, Jano B, Fasal P, Shepard CC. Acedapsone in the prevention of leprosy: field trial in three high prevalence villages in Micronesia. Am J Trop Med Hyg. 1979 May;28(3):559-63. PubMed PMID: 453449.
5: Peters JH, Murray JF Jr, Gordon GR, Levy L, Russell DA, Scott GC, Vincin DR, Shepard CC. Acedapsone treatment of leprosy patients: response versus drug disposition. Am J Trop Med Hyg. 1977 Jan;26(1):127-36. PubMed PMID: 842774.
6: Levy L, Peters JH. Susceptibility of Mycobacterium leprae to dapsone as a determinant of patient response to acedapsone. Antimicrob Agents Chemother. 1976 Jan;9(1):102-12. PubMed PMID: 769667; PubMed Central PMCID: PMC429483.
7: Russell DA, Shepard CC, McRae DH, Scott GC, Vincin DR. Acedapsone (DADDS) treatment of leprosy patients in the Karimui of Papua New Guinea: status at six years. Am J Trop Med Hyg. 1975 May;24(3):485-95. PubMed PMID: 1098496.