WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584121
CAS#: 36499-65-7
Description: Dicobalt edetate is one of a number of cobalt compounds that have been studied in the treatment of cyanide poisoning, their efficacy being based upon the fact that cyanide combines with cobalt to form relatively non-toxic complexes.
Hodoodo Cat#: H584121
Name: Dicobalt edetate
CAS#: 36499-65-7
Chemical Formula: C10H12Co2N2O8
Exact Mass: 0.00
Molecular Weight: 406.070
Elemental Analysis: C, 29.58; H, 2.98; Co, 29.03; N, 6.90; O, 31.52
This product is not in stock, which may be available by custom synthesis.
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Synonym: Dicobalt edetate; Ba 2724; Ba-2724; Ba2724; Kelocyanor
IUPAC/Chemical Name: Dicobalt edetate
InChi Key: TWAWHTJKASJPEK-UHFFFAOYSA-J
InChi Code: InChI=1S/C10H16N2O8.2Co/c13-7(14)3-11(4-8(15)16)1-2-12(5-9(17)18)6-10(19)20;;/h1-6H2,(H,13,14)(H,15,16)(H,17,18)(H,19,20);;/q;2*+2/p-4
SMILES Code: [O-]C(CN(CCN(CC([O-])=O)CC([O-])=O)CC([O-])=O)=O.[Co+2].[Co+2]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 406.07 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Marrs TC, Thompson JP. The efficacy and adverse effects of dicobalt edetate in cyanide poisoning. Clin Toxicol (Phila). 2016 Sep;54(8):609-14. doi: 10.1080/15563650.2016.1186804. Epub 2016 Jun 28. Review. PubMed PMID: 27352227.
2: Hill SL, Thomas SH, Flecknell PA, Thomas AA, Morris CM, Henderson D, Dunn M, Blain PG. Rapid and equivalent systemic bioavailability of the antidotes HI-6 and dicobalt edetate via the intraosseous and intravenous routes. Emerg Med J. 2015 Aug;32(8):626-31. doi: 10.1136/emermed-2014-204171. Epub 2014 Nov 20. PubMed PMID: 25414476.
3: Marrs TC, Swanston DW, Bright JE. 4-Dimethylaminophenol and dicobalt edetate (Kelocyanor) in the treatment of experimental cyanide poisoning. Hum Toxicol. 1985 Nov;4(6):591-600. PubMed PMID: 3935565.