WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584131
CAS#: 325795-25-3
Description: BB-83698 is a peptide deformylase inhibitor and potent antimicrobial with excellent activity against streptococci and Moraxella catarrhalis strains.
Hodoodo Cat#: H584131
Name: BB-83698
CAS#: 325795-25-3
Chemical Formula: C28H42N4O6
Exact Mass: 530.31
Molecular Weight: 530.666
Elemental Analysis: C, 63.37; H, 7.98; N, 10.56; O, 18.09
Synonym: BB-83698; BB 83698; BB83698
IUPAC/Chemical Name: Cyclopentanepropanamide, N-((1S)-1-((4-(1,3-benzodioxol-5-ylmethyl)-1-piperazinyl)carbonyl)-2,2-dimethylpropyl)-alpha-((formylhydroxyamino)methyl)-, (alphaR)-
InChi Key: IBEANEPZNLVRRY-RCZVLFRGSA-N
InChi Code: InChI=1S/C28H42N4O6/c1-28(2,3)25(29-26(34)22(17-32(36)18-33)14-20-6-4-5-7-20)27(35)31-12-10-30(11-13-31)16-21-8-9-23-24(15-21)38-19-37-23/h8-9,15,18,20,22,25,36H,4-7,10-14,16-17,19H2,1-3H3,(H,29,34)/t22-,25-/m1/s1
SMILES Code: O=C(N[C@H](C(N1CCN(CC2=CC=C(OCO3)C3=C2)CC1)=O)C(C)(C)C)[C@@H](CN(C=O)O)CC4CCCC4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | BB-83698 is a peptide deformylase inhibitor and potent antimicrobial. |
In vitro activity: | BB-83698 demonstrated potent in vitro activity against all of the strains, regardless of preexisting resistance mechanisms (MICs, 0.06 to 0.25 μg/ml) (Table 1). Reference: Antimicrob Agents Chemother. 2004 Jan;48(1):80-5. https://pubmed.ncbi.nlm.nih.gov/14693522/ |
In vivo activity: | Mice infected with penicillin-susceptible and macrolide-resistant strain P-6254 (erythromycin MIC, 1,024 μg/ml) had 10-day survival rates of 100% when they were treated with BB-83698 at 80 mg/kg/12 h or 160 mg/kg/24 h starting at 6 h postinfection. Comparator mice treated with erythromycin or azithromycin at 100 mg/kg/12 h had 10-day survival rates of only 30% (Fig. 1B). Treatment with amoxicillin at 5 mg/kg protected 80% of mice. Reference: Antimicrob Agents Chemother. 2004 Jan;48(1):80-5. https://pubmed.ncbi.nlm.nih.gov/14693522/ |
The following data is based on the product molecular weight 530.67 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | 1. Azoulay-Dupuis E, Mohler J, Bédos JP. Efficacy of BB-83698, a novel peptide deformylase inhibitor, in a mouse model of pneumococcal pneumonia. Antimicrob Agents Chemother. 2004 Jan;48(1):80-5. doi: 10.1128/AAC.48.1.80-85.2004. PMID: 14693522; PMCID: PMC310171. |
In vitro protocol: | 1. Azoulay-Dupuis E, Mohler J, Bédos JP. Efficacy of BB-83698, a novel peptide deformylase inhibitor, in a mouse model of pneumococcal pneumonia. Antimicrob Agents Chemother. 2004 Jan;48(1):80-5. doi: 10.1128/AAC.48.1.80-85.2004. PMID: 14693522; PMCID: PMC310171. |
In vivo protocol: | 1. Azoulay-Dupuis E, Mohler J, Bédos JP. Efficacy of BB-83698, a novel peptide deformylase inhibitor, in a mouse model of pneumococcal pneumonia. Antimicrob Agents Chemother. 2004 Jan;48(1):80-5. doi: 10.1128/AAC.48.1.80-85.2004. PMID: 14693522; PMCID: PMC310171. |
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3: Wang Q, Wang J, Cai Z, Xu W. Prediction of the binding modes between BB-83698 and peptide deformylase from Bacillus stearothermophilus by docking and molecular dynamics simulation. Biophys Chem. 2008 May;134(3):178-84. doi: 10.1016/j.bpc.2008.02.003. Epub 2008 Feb 16. PubMed PMID: 18321635.
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