WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584141
CAS#: 101-21-3
Description: Chlorpropham is an agricultural chemical that acts as a plant growth regulator and herbicide.
Hodoodo Cat#: H584141
Name: Chlorpropham
CAS#: 101-21-3
Chemical Formula: C10H12ClNO2
Exact Mass: 213.06
Molecular Weight: 213.660
Elemental Analysis: C, 56.22; H, 5.66; Cl, 16.59; N, 6.56; O, 14.98
Synonym: Chlorpropham; Metoxon; Mirvale; Preventol; Bud Nip; Nexoval; Furloe; Taterpex
IUPAC/Chemical Name: Carbamic acid, (3-chlorophenyl)-, 1-methylethyl ester
InChi Key: CWJSHJJYOPWUGX-UHFFFAOYSA-N
InChi Code: InChI=1S/C10H12ClNO2/c1-7(2)14-10(13)12-9-5-3-4-8(11)6-9/h3-7H,1-2H3,(H,12,13)
SMILES Code: O=C(OC(C)C)NC1=CC=CC(Cl)=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 213.66 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Li Y, Zhang G, Tao M. Binding properties of herbicide chlorpropham to DNA: spectroscopic, chemometrics and modeling investigations. J Photochem Photobiol B. 2014 Sep 5;138:109-17. doi: 10.1016/j.jphotobiol.2014.05.011. Epub 2014 May 27. PubMed PMID: 24927231.
2: Huang Z, Tian S, Ge X, Zhang J, Li S, Li M, Cheng J, Zheng H. Complexation of chlorpropham with hydroxypropyl-β-cyclodextrin and its application in potato sprout inhibition. Carbohydr Polym. 2014 Jul 17;107:241-6. doi: 10.1016/j.carbpol.2014.02.072. Epub 2014 Mar 12. PubMed PMID: 24702941.
3: Passananti M, Lavorgna M, Iesce MR, DellaGreca M, Criscuolo E, Parrella A, Isidori M, Temussi F. Chlorpropham and phenisopham: phototransformation and ecotoxicity of carbamates in the aquatic environment. Environ Sci Process Impacts. 2014 Apr;16(4):823-31. doi: 10.1039/c3em00400g. PubMed PMID: 24166079.
4: Berchtold C, Müller V, Meier L, Schmid S, Zenobi R. Direct detection of chlorpropham on potato skin using desorption electrospray ionization. J Mass Spectrom. 2013 May;48(5):587-93. doi: 10.1002/jms.3197. PubMed PMID: 23674283.
5: Smith MJ, Müller S, Sander W, Bucher G. Mechanisms of the thermal decay of chlorpropham. J Hazard Mater. 2013 Feb 15;246-247:154-62. doi: 10.1016/j.jhazmat.2012.12.003. Epub 2012 Dec 10. PubMed PMID: 23295769.
6: Smith MJ, Bucher G. Tools to study the degradation and loss of the N-phenyl carbamate chlorpropham--a comprehensive review. Environ Int. 2012 Nov 15;49:38-50. doi: 10.1016/j.envint.2012.08.005. Epub 2012 Sep 13. Review. PubMed PMID: 22982221.
7: Campbell MA, Gleichsner A, Alsbury R, Horvath D, Suttle J. The sprout inhibitors chlorpropham and 1,4-dimethylnaphthalene elicit different transcriptional profiles and do not suppress growth through a prolongation of the dormant state. Plant Mol Biol. 2010 May;73(1-2):181-9. doi: 10.1007/s11103-010-9607-6. Epub 2010 Feb 5. PubMed PMID: 20135197.
8: Sakaliene O, Koskinen WC, Blazauskiene G, Petroviene I. Level and fate of chlorpropham in potatoes during storage and processing. J Environ Sci Health B. 2009 Jan;44(1):1-6. doi: 10.1080/03601230802519470. PubMed PMID: 19089708.
9: Kuehl PJ, Brenner T, Jain PK, Karlage K, Sepassi K, Yang G, Mayersohn M, Yalkowsky SH, Myrdal PB. Formulation and in vivo evaluation of chlorpropham (CIPC) oral formulations. J Pharm Sci. 2008 Dec;97(12):5222-8. doi: 10.1002/jps.21384. PubMed PMID: 18383335.
10: Orejuela E, Silva M. Rapid determination of aniline metabolites of chlorpropham in potatoes by micellar electrokinetic chromatography using negative-charged mixed micelles and laser-induced fluorescence detection. Electrophoresis. 2005 Aug;26(15):2991-8. PubMed PMID: 15995980.
11: Fujitani T, Tada Y, Yoneyama M. Chlorpropham-induced splenotoxicity and its recovery in rats. Food Chem Toxicol. 2004 Sep;42(9):1469-77. PubMed PMID: 15234077.
12: Nakagawa Y, Nakajima K, Suzuki T. Chlorpropham induces mitochondrial dysfunction in rat hepatocytes. Toxicology. 2004 Aug 5;200(2-3):123-33. PubMed PMID: 15212809.
13: Nakagawa Y, Nakajima K, Suzuki T. Biotransformation of chlorpropham (CIPC) in isolated rat hepatocytes and xenoestrogenic activity of CIPC and its metabolites by in vitro assays. Xenobiotica. 2004 Mar;34(3):257-72. PubMed PMID: 15204698.
14: Noël S, Huyghebaert B, Pigeon O, Weickmans B, Mostade O. The heterogeneity of sprout inhibitor application with chlorpropham. Commun Agric Appl Biol Sci. 2003;68(4 Pt B):739-48. PubMed PMID: 15151310.
15: Franzaring J, Kempenaar C, van der Eerden LJ. Effects of vapours of chlorpropham and ethofumesate on wild plant species. Environ Pollut. 2001;114(1):21-8. PubMed PMID: 11444003.
16: Fujitani T, Tada Y, Noguchi AT, Yoneyama M. Effects of chlorpropham (CIPC) on the hemopoietic system of rats. Food Chem Toxicol. 2001 Mar;39(3):253-9. PubMed PMID: 11278057.
17: Lentza-Rizos C, Balokas A. Residue levels of chlorpropham in individual tubers and composite samples of postharvest-treated potatoes. J Agric Food Chem. 2001 Feb;49(2):710-4. PubMed PMID: 11262017.
18: Fujitani T, Tada Y, Fujii A, Kimura M, Yoneyama M. Subchronic toxicity of chlorpropham (CIPC) in ICR mice. Food Chem Toxicol. 2000 Jul;38(7):617-25. PubMed PMID: 10942323.
19: Tanaka T. Reproductive and neurobehavioural toxicity study of chlorpropham in mice. Food Addit Contam. 1999 Apr;16(4):173-80. PubMed PMID: 10560570.
20: Holy J. Chlorpropham [isopropyl N-(3-chlorophenyl) carbamate] disrupts microtubule organization, cell division, and early development of sea urchin embryos. J Toxicol Environ Health A. 1998 Jun 26;54(4):319-33. PubMed PMID: 9638902.