Dichlorvos
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Hodoodo CAT#: H584152

CAS#: 62-73-7

Description: Dichlorvos is an organophosphorus insecticide that inhibits acetylcholinesterase.


Chemical Structure

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Dichlorvos
CAS# 62-73-7

Theoretical Analysis

Hodoodo Cat#: H584152
Name: Dichlorvos
CAS#: 62-73-7
Chemical Formula: C4H7Cl2O4P
Exact Mass: 219.95
Molecular Weight: 220.960
Elemental Analysis: C, 21.74; H, 3.19; Cl, 32.09; O, 28.96; P, 14.02

Price and Availability

Size Price Availability Quantity
100mg USD 250 2 Weeks
250mg USD 400 2 weeks
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Synonym: Dichlorvos; Deriban; Fekama; Fly-Die; Herkal; Marvex; Nerkol; Tenac; Unitox; Vapona; XLP 30; XLP-30; XLP30

IUPAC/Chemical Name: Phosphoric acid, 2,2-dichlorovinyl dimethyl ester

InChi Key: OEBRKCOSUFCWJD-UHFFFAOYSA-N

InChi Code: InChI=1S/C4H7Cl2O4P/c1-8-11(7,9-2)10-3-4(5)6/h3H,1-2H3

SMILES Code: O=P(OC)(OC)O/C=C(Cl)\Cl

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 220.96 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Christian S, Pradhan P, Jans U. Investigation of the Nucleophilic Attack of Dichlorvos by Reduced Sulfur Species using (1)H NMR. J Agric Food Chem. 2017 Dec 9. doi: 10.1021/acs.jafc.7b04749. [Epub ahead of print] PubMed PMID: 29224357.

2: Eftekhari A, Ahmadian E, Azami A, Johari-Ahar M, Eghbal MA. Protective effects of coenzyme Q10 nanoparticles on dichlorvos-induced hepatotoxicity and mitochondrial/lysosomal injury. Environ Toxicol. 2017 Nov 16. doi: 10.1002/tox.22505. [Epub ahead of print] PubMed PMID: 29143438.

3: Mohammadi H, Jalilian J, Karimi MY, Shetab-Boushehri SV. In Vitro Cysteine Reactivates Organophosphate Insecticide Dichlorvos-Inhibited Human Cholinesterases. Sultan Qaboos Univ Med J. 2017 Aug;17(3):e293-e300. doi: 10.18295/squmj.2017.17.03.006. Epub 2017 Oct 10. PubMed PMID: 29062551; PubMed Central PMCID: PMC5642358.

4: Kanu KC, Ijioma SN, Atiata O. Haematological, Biochemical and Antioxidant Changes in Wistar Rats Exposed to Dichlorvos Based Insecticide Formulation Used in Southeast Nigeria. Toxics. 2016 Nov 29;4(4). pii: E28. doi: 10.3390/toxics4040028. PubMed PMID: 29051431; PubMed Central PMCID: PMC5606651.

5: Akande MG, Ahmed US. Taurine abated subacute dichlorvos toxicity. Toxicol Rep. 2017 Aug 30;4:463-466. doi: 10.1016/j.toxrep.2017.08.001. eCollection 2017. PubMed PMID: 28959675; PubMed Central PMCID: PMC5615161.

6: Zhang Y, You JZ, Zhou Y, Zhang PW, Qin Q, Zhang ZX. The effect of dichlorvos on control of drosophila and its safety evaluation under different application methods. Environ Sci Pollut Res Int. 2017 Oct;24(29):22940-22947. doi: 10.1007/s11356-017-9879-3. Epub 2017 Aug 16. PubMed PMID: 28815365.

7: Oyagbemi AA, Omobowale TO, Ochigbo GO, Asenuga ER, Ola-Davies OE, Ajibade TO, Saba AB, Adedapo AA. Polyphenol-Rich Fraction of Parquetina nigrescens Mitigates Dichlorvos-Induced Cardiorenal Dysfunction Through Reduction in Cardiac Nitrotyrosine and Renal p38 Expressions in Wistar Rats. J Diet Suppl. 2017 Aug 11:1-16. doi: 10.1080/19390211.2017.1336148. [Epub ahead of print] PubMed PMID: 28800275.

8: García-Rojo G, Gámiz F, Ampuero E, Rojas-Espina D, Sandoval R, Rozas C, Morales B, Wyneken U, Pancetti F. In Vivo Sub-chronic Treatment with Dichlorvos in Young Rats Promotes Synaptic Plasticity and Learning by a Mechanism that Involves Acylpeptide Hydrolase Instead of Acetylcholinesterase Inhibition. Correlation with Endogenous β-Amyloid Levels. Front Pharmacol. 2017 Jul 25;8:483. doi: 10.3389/fphar.2017.00483. eCollection 2017. PubMed PMID: 28790916; PubMed Central PMCID: PMC5524899.

9: Zhang X, Cheng S. Intramolecular Halogen Atom Coordinated H Transfer via Ion-Neutral Complex in the Gas Phase Dissociation of Protonated Dichlorvos Derivatives. J Am Soc Mass Spectrom. 2017 Oct;28(10):2246-2254. doi: 10.1007/s13361-017-1736-6. Epub 2017 Jul 5. PubMed PMID: 28681359.

10: Ibrahim IA, Abbas AM, Darwish HM. Fluorescence sensing of dichlorvos pesticide by the luminescent Tb(III)-3-ally-salicylohydrazide probe. Luminescence. 2017 Dec;32(8):1541-1546. doi: 10.1002/bio.3357. Epub 2017 Jun 29. PubMed PMID: 28660707.

11: Kumar P, Swami D, Karade HN, Singh M, Tiwari A, Singh KP. Protection studies of new bis quaternary 2-(hydroxyimino)-N-(pyridin-3yl) acetamide derivatives (HNK-series) oximes against acute poisoning by dichlorvos (DDVP) in Swiss albino mice. Interdiscip Toxicol. 2016 Dec;9(3-4):101-105. doi: 10.1515/intox-2016-0013. Epub 2017 May 17. PubMed PMID: 28652853; PubMed Central PMCID: PMC5464681.

12: Shiyovich A, Matot R, Elyagon S, Liel-Cohen N, Rosman Y, Shrot S, Kassirer M, Katz A, Etzion Y. QT Prolongation as an Isolated Long-Term Cardiac Manifestation of Dichlorvos Organophosphate Poisoning in Rats. Cardiovasc Toxicol. 2017 May 16. doi: 10.1007/s12012-017-9409-z. [Epub ahead of print] PubMed PMID: 28510081.

13: Mehrotra N, Tripathi RM, Zafar F, Singh MP. Catalytic Degradation of Dichlorvos Using Biosynthesized Zero Valent Iron Nanoparticles. IEEE Trans Nanobioscience. 2017 Jun;16(4):280-286. doi: 10.1109/TNB.2017.2700232. Epub 2017 May 2. PubMed PMID: 28475065.

14: Chaudhary B, Bist R. Protective manifestation of bacoside A and bromelain in terms of cholinesterases, gamma-amino butyric acid, serotonin level and stress proteins in the brain of dichlorvos-intoxicated mice. Cell Stress Chaperones. 2017 May;22(3):371-376. doi: 10.1007/s12192-017-0773-1. Epub 2017 Mar 20. PubMed PMID: 28321764; PubMed Central PMCID: PMC5425367.

15: Ochigbo GO, Saba AB, Oyagbemi AA, Omobowale TO, Asenuga ER. Polyphenol-rich fraction of Parquetina nigrescens mitigates dichlorvos-induced neurotoxicity and apoptosis. J Ayurveda Integr Med. 2017 Jan - Mar;8(1):27-36. doi: 10.1016/j.jaim.2016.09.002. Epub 2017 Feb 28. PubMed PMID: 28256303; PubMed Central PMCID: PMC5377485.

16: Oribhabor BJ, Ikeogu GC. Acute Toxicity of the Pesticides, Dichlorvos and Lindane against the African air-breathing catfish, Heterobranchus longifilis, Valenciennes, 1840 (Siluriformes: Clariidae). Recent Pat Biotechnol. 2016;10(3):272-278. PubMed PMID: 28236669.

17: Agarwal S, Chaudhary B, Bist R. Protective propensity of bacoside A and bromelain on renal cholinesterases, γ-Aminobutyric acid and serotonin level of Mus musculus intoxicated with dichlorvos. Chem Biol Interact. 2017 Jan 5;261:139-144. doi: 10.1016/j.cbi.2016.11.027. Epub 2016 Nov 27. PubMed PMID: 27899289.

18: Cheng X. TD-M06-2X insights into the absorption and emission spectra of dichlorvos and its molecularly imprinted recognition by methacrylic acid. J Mol Model. 2016 Nov;22(11):282. Epub 2016 Oct 29. PubMed PMID: 27796784.

19: Otto MA, Martin NJ, Rous JS, Stevens ME Jr. Determination of airborne concentrations of dichlorvos over a range of temperatures when using commercially available pesticide strips in a simulated military guard post. J Occup Environ Hyg. 2017 Apr;14(4):D54-D61. doi: 10.1080/15459624.2016.1250008. PubMed PMID: 27754812.

20: Ben Salem I, Boussabbeh M, Kantaoui H, Bacha H, Abid-Essefi S. Crocin, the main active saffron constituent, mitigates dichlorvos-induced oxidative stress and apoptosis in HCT-116 cells. Biomed Pharmacother. 2016 Aug;82:65-71. doi: 10.1016/j.biopha.2016.04.063. Epub 2016 May 6. PubMed PMID: 27470340.