Cinnamaldehyde
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Hodoodo CAT#: H571374

CAS#: 104-55-2

Description: Cinnamaldehyde is a flavoring agent. It has been investigated as an antimutagen, but some studies show that effectively high doses may actually promote cancer mutations. It may play a role as an anti-inflammatory agent and alleviate pressure in vascular regions.


Chemical Structure

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Cinnamaldehyde
CAS# 104-55-2

Theoretical Analysis

Hodoodo Cat#: H571374
Name: Cinnamaldehyde
CAS#: 104-55-2
Chemical Formula: C9H8O
Exact Mass: 132.06
Molecular Weight: 132.160
Elemental Analysis: C, 81.79; H, 6.10; O, 12.11

Price and Availability

Size Price Availability Quantity
5g USD 250 2 Weeks
25g USD 450 2 Weeks
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Synonym: Cinnamaldehyde

IUPAC/Chemical Name: 2-Propenal, 3-phenyl-

InChi Key: KJPRLNWUNMBNBZ-QPJJXVBHSA-N

InChi Code: InChI=1S/C9H8O/c10-8-4-7-9-5-2-1-3-6-9/h1-8H/b7-4+

SMILES Code: O=C/C=C/C1=CC=CC=C1

Appearance: Liquid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 132.16 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Yang L, Wu QQ, Liu Y, Hu ZF, Bian ZY, Tang QZ. Cinnamaldehyde attenuates pressure overload-induced cardiac hypertrophy. Int J Clin Exp Pathol. 2015 Nov 1;8(11):14345-54. eCollection 2015. PubMed PMID: 26823750; PubMed Central PMCID: PMC4713536.

2: Zhao J, Zhang X, Dong L, Wen Y, Zheng X, Zhang C, Chen R, Zhang Y, Li Y, He T, Zhu X, Li L. Cinnamaldehyde inhibits inflammation and brain damage in a mouse model of permanent cerebral ischaemia. Br J Pharmacol. 2015 Oct;172(20):5009-23. doi: 10.1111/bph.13270. Epub 2015 Oct 14. PubMed PMID: 26234631; PubMed Central PMCID: PMC4621990.

3: Huang JS, Lee YH, Chuang LY, Guh JY, Hwang JY. Cinnamaldehyde and nitric oxide attenuate advanced glycation end products-induced the Jak/STAT signaling in human renal tubular cells. J Cell Biochem. 2015 Jun;116(6):1028-38. doi: 10.1002/jcb.25058. PubMed PMID: 25561392.

4: Shreaz S, Wani WA, Behbehani JM, Raja V, Irshad M, Karched M, Ali I, Siddiqi WA, Hun LT. Cinnamaldehyde and its derivatives, a novel class of antifungal agents. Fitoterapia. 2016 Jul;112:116-31. doi: 10.1016/j.fitote.2016.05.016. Epub 2016 May 31. Review. PubMed PMID: 27259370.

5: Liang D, Xing F, Selvaraj JN, Liu X, Wang L, Hua H, Zhou L, Zhao Y, Wang Y, Liu Y. Inhibitory Effect of Cinnamaldehyde, Citral, and Eugenol on Aflatoxin Biosynthetic Gene Expression and Aflatoxin B1 Biosynthesis in Aspergillus flavus. J Food Sci. 2015 Dec;80(12):M2917-24. doi: 10.1111/1750-3841.13144. Epub 2015 Nov 10. PubMed PMID: 26556681.

6: Bang HB, Lee YH, Kim SC, Sung CK, Jeong KJ. Metabolic engineering of Escherichia coli for the production of cinnamaldehyde. Microb Cell Fact. 2016 Jan 19;15:16. doi: 10.1186/s12934-016-0415-9. PubMed PMID: 26785776; PubMed Central PMCID: PMC4719340.

7: Yu C, Liu SL, Qi MH, Zou X. Cinnamaldehyde/chemotherapeutic agents interaction and drug-metabolizing genes in colorectal cancer. Mol Med Rep. 2014 Feb;9(2):669-76. doi: 10.3892/mmr.2013.1830. Epub 2013 Nov 26. PubMed PMID: 24276478.

8: Raffai G, Kim B, Park S, Khang G, Lee D, Vanhoutte PM. Cinnamaldehyde and cinnamaldehyde-containing micelles induce relaxation of isolated porcine coronary arteries: role of nitric oxide and calcium. Int J Nanomedicine. 2014 May 21;9:2557-66. doi: 10.2147/IJN.S56578. eCollection 2014. PubMed PMID: 24904214; PubMed Central PMCID: PMC4039418.

9: Zhang LQ, Zhang ZG, Fu Y, Xu Y. [Research progress of trans-cinnamaldehyde pharmacological effects]. Zhongguo Zhong Yao Za Zhi. 2015 Dec;40(23):4568-72. Review. Chinese. PubMed PMID: 27141665.

10: Mendes SJ, Sousa FI, Pereira DM, Ferro TA, Pereira IC, Silva BL, Pinheiro AJ, Mouchrek AQ, Monteiro-Neto V, Costa SK, Nascimento JL, Grisotto MA, da Costa R, Fernandes ES. Cinnamaldehyde modulates LPS-induced systemic inflammatory response syndrome through TRPA1-dependent and independent mechanisms. Int Immunopharmacol. 2016 May;34:60-70. doi: 10.1016/j.intimp.2016.02.012. Epub 2016 Feb 26. PubMed PMID: 26922677.

11: Khare P, Jagtap S, Jain Y, Baboota RK, Mangal P, Boparai RK, Bhutani KK, Sharma SS, Premkumar LS, Kondepudi KK, Chopra K, Bishnoi M. Cinnamaldehyde supplementation prevents fasting-induced hyperphagia, lipid accumulation, and inflammation in high-fat diet-fed mice. Biofactors. 2016 Mar-Apr;42(2):201-11. doi: 10.1002/biof.1265. Epub 2016 Feb 19. PubMed PMID: 26893251.

12: Højland CR, Andersen HH, Poulsen JN, Arendt-Nielsen L, Gazerani P. A human surrogate model of itch utilizing the TRPA1 agonist trans-cinnamaldehyde. Acta Derm Venereol. 2015 Sep;95(7):798-803. doi: 10.2340/00015555-2103. PubMed PMID: 25792226.

13: Zinn S, Betz T, Medcraft C, Schnell M. Structure determination of trans-cinnamaldehyde by broadband microwave spectroscopy. Phys Chem Chem Phys. 2015 Jun 28;17(24):16080-5. doi: 10.1039/c5cp02582f. Epub 2015 Jun 1. PubMed PMID: 26030313.

14: Ji B, Zhao Y, Zhang Q, Wang P, Guan J, Rong R, Yu Z. Simultaneous determination of cinnamaldehyde, cinnamic acid, and 2-methoxy cinnamic acid in rat whole blood after oral administration of volatile oil of Cinnamoni Ramulus by UHPLC-MS/MS: An application for a pharmacokinetic study. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Sep 15;1001:107-13. doi: 10.1016/j.jchromb.2015.07.049. Epub 2015 Aug 1. PubMed PMID: 26262602.

15: Loquercio A, Castell-Perez E, Gomes C, Moreira RG. Preparation of Chitosan-Alginate Nanoparticles for Trans-cinnamaldehyde Entrapment. J Food Sci. 2015 Oct;80(10):N2305-15. doi: 10.1111/1750-3841.12997. Epub 2015 Sep 16. PubMed PMID: 26375302.

16: Ahn S, Kim E, Lee K, Lee DC. Cinnamaldehyde derivatives inhibit degranulation and inflammatory mediator production in rat basophilic leukemia cells. Int Immunopharmacol. 2016 Sep;38:342-8. doi: 10.1016/j.intimp.2016.06.018. Epub 2016 Jun 23. PubMed PMID: 27344640.

17: Ling F, Jiang C, Liu G, Li M, Wang G. Anthelmintic efficacy of cinnamaldehyde and cinnamic acid from cortex cinnamon essential oil against Dactylogyrus intermedius. Parasitology. 2015 Dec;142(14):1744-50. doi: 10.1017/S0031182015001031. Epub 2015 Oct 7. PubMed PMID: 26442478.

18: Roth-Walter F, Moskovskich A, Gomez-Casado C, Diaz-Perales A, Oida K, Singer J, Kinaciyan T, Fuchs HC, Jensen-Jarolim E. Immune suppressive effect of cinnamaldehyde due to inhibition of proliferation and induction of apoptosis in immune cells: implications in cancer. PLoS One. 2014 Oct 1;9(10):e108402. doi: 10.1371/journal.pone.0108402. eCollection 2014. PubMed PMID: 25271635; PubMed Central PMCID: PMC4182734.

19: Zhou L, Lu Y, Yang G, Wu J. Research on tumorigenicity of cinnamaldehyde in melanoma cell lines and its mechanism. Tumour Biol. 2014 Jun;35(6):5717-22. doi: 10.1007/s13277-014-1757-8. Epub 2014 Mar 19. PubMed PMID: 24643680.

20: Yang D, Liang XC, Shi Y, Sun Q, Liu D, Liu W, Zhang H. Anti-oxidative and anti-inflammatory effects of cinnamaldehyde on protecting high glucose-induced damage in cultured dorsal root ganglion neurons of rats. Chin J Integr Med. 2016 Jan;22(1):19-27. doi: 10.1007/s11655-015-2103-8. Epub 2015 Nov 17. PubMed PMID: 26577110.