WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H527016
CAS#: 112410-23-8
Description: Tebufenozide is a novel nonsteroidal ecdysone agonist, exhibiting good efficacy and playing an increasingly important role in the control of Lepidopteran pests.
Hodoodo Cat#: H527016
Name: Tebufenozide
CAS#: 112410-23-8
Chemical Formula: C22H28N2O2
Exact Mass: 352.22
Molecular Weight: 352.478
Elemental Analysis: C, 74.97; H, 8.01; N, 7.95; O, 9.08
This product is not in stock, which may be available by custom synthesis.
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Synonym: Tebufenozide
IUPAC/Chemical Name: N-tert-Butyl-N'-(4-ethylbenzoyl)-3,5-dimethylbenzohydrazide
InChi Key: QYPNKSZPJQQLRK-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H28N2O2/c1-7-17-8-10-18(11-9-17)20(25)23-24(22(4,5)6)21(26)19-13-15(2)12-16(3)14-19/h8-14H,7H2,1-6H3,(H,23,25)
SMILES Code: O=C(N(C(C)(C)C)NC(C1=CC=C(CC)C=C1)=O)C2=CC(C)=CC(C)=C2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 352.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Bosch D, Rodríguez MA, Avilla J. Monitoring resistance of Cydia pomonella (L.) Spanish field populations to new chemical insecticides and the mechanisms involved. Pest Manag Sci. 2017 Nov 16. doi: 10.1002/ps.4791. [Epub ahead of print] PubMed PMID: 29148167.
2: Wang Y, Xu F, Yu G, Shi J, Li C, Dai A, Liu Z, Xu J, Wang F, Wu J. Synthesis and insecticidal activity of diacylhydrazine derivatives containing a 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole scaffold. Chem Cent J. 2017 Jun 5;11(1):50. doi: 10.1186/s13065-017-0279-z. PubMed PMID: 29086837; PubMed Central PMCID: PMC5459783.
3: Camara MA, Barba A, Cermeño S, Martinez G, Oliva J. Effect of processing on the disappearance of pesticide residues in fresh-cut lettuce: Bioavailability and dietary risk. J Environ Sci Health B. 2017 Dec 2;52(12):880-886. doi: 10.1080/03601234.2017.1361767. Epub 2017 Sep 26. PubMed PMID: 28949798.
4: Franco AA, Zanardi OZ, Jacob CRO, de Oliveira MBR, Yamamoto PT. Susceptibility of Euseius concordis (Mesostigmata: Phytoseiidae) to pesticides used in citrus production systems. Exp Appl Acarol. 2017 Sep;73(1):61-77. doi: 10.1007/s10493-017-0176-0. Epub 2017 Sep 2. PubMed PMID: 28866797.
5: Cabrera AR, Shirk PD, Teal PEA. A feeding protocol for delivery of agents to assess development in Varroa mites. PLoS One. 2017 Apr 27;12(4):e0176097. doi: 10.1371/journal.pone.0176097. eCollection 2017. PubMed PMID: 28448606; PubMed Central PMCID: PMC5407785.
6: Kasiotis KM, Tsakirakis AN, Richard Glass C, Charistou AN, Anastassiadou P, Gerritsen-Ebben R, Machera K. Assessment of field re-entry exposure to pesticides: A dislodgeable foliar residue study. Sci Total Environ. 2017 Oct 15;596-597:178-186. doi: 10.1016/j.scitotenv.2017.04.016. Epub 2017 Apr 19. PubMed PMID: 28432907.
7: Wilson BE, VanWeelden MT, Beuzelin JM, Reagan TE, Prado JA. Efficacy of Insect Growth Regulators and Diamide Insecticides for Control of Stem Borers (Lepidoptera: Crambidae) in Sugarcane. J Econ Entomol. 2017 Apr 1;110(2):453-463. doi: 10.1093/jee/tow305. PubMed PMID: 28334153.
8: Zdolšek N, Kumrić K, Kalijadis A, Trtić-Petrović T. Solid-phase extraction disk based on multiwalled carbon nanotubes for the enrichment of targeted pesticides from aqueous samples. J Sep Sci. 2017 Apr;40(7):1564-1571. doi: 10.1002/jssc.201600957. Epub 2017 Mar 17. PubMed PMID: 28160421.
9: Chai Y, Gao G, Shen S, Liu X, Lu C. Neutral losses of sodium benzoate and benzoic acid in the fragmentation of the [M + Na](+) ions of methoxyfenozide and tebufenozide via intramolecular rearrangement in electrospray ionization tandem mass spectrometry. Rapid Commun Mass Spectrom. 2017 Feb 15;31(3):245-252. doi: 10.1002/rcm.7785. PubMed PMID: 28110498.
10: Xu W, Wang B, Yang M, Zhang Y, Xu Z, Yang Y, Cao H, Tao L. Tebufenozide induces G1/S cell cycle arrest and apoptosis in human cells. Environ Toxicol Pharmacol. 2017 Jan;49:89-96. doi: 10.1016/j.etap.2016.12.002. Epub 2016 Dec 8. PubMed PMID: 27960113.
11: Liu Y, Li X, Zhou C, Liu F, Mu W. Toxicity of nine insecticides on four natural enemies of Spodoptera exigua. Sci Rep. 2016 Dec 13;6:39060. doi: 10.1038/srep39060. PubMed PMID: 27958333; PubMed Central PMCID: PMC5153630.
12: Ono ÉK, Zanardi OZ, Aguiar Santos KF, Yamamoto PT. Susceptibility of Ceraeochrysa cubana larvae and adults to six insect growth-regulator insecticides. Chemosphere. 2017 Feb;168:49-57. doi: 10.1016/j.chemosphere.2016.10.061. Epub 2016 Oct 22. PubMed PMID: 27776238.
13: Abass KM. An investigation into the formation of tebufenozide's toxic aromatic amine metabolites in human in vitro hepatic microsomes. Pestic Biochem Physiol. 2016 Oct;133:73-78. doi: 10.1016/j.pestbp.2016.03.001. Epub 2016 Mar 4. PubMed PMID: 27742364.
14: Lee S, Sohn KC, Choi DK, Won M, Park KA, Ju SK, Kang K, Bae YK, Hur GM, Ro H. Ecdysone Receptor-based Singular Gene Switches for Regulated Transgene Expression in Cells and Adult Rodent Tissues. Mol Ther Nucleic Acids. 2016 Sep 27;5(9):e367. doi: 10.1038/mtna.2016.74. PubMed PMID: 27673563; PubMed Central PMCID: PMC5056996.
15: Liu J, Rashid M, Qi J, Hu M, Zhong G. Dissipation and metabolism of tebufenozide in cabbage and soil under open field conditions in South China. Ecotoxicol Environ Saf. 2016 Dec;134P1:204-212. doi: 10.1016/j.ecoenv.2016.09.002. Epub 2016 Sep 14. PubMed PMID: 27636325.
16: LaLone CA, Villeneuve DL, Lyons D, Helgen HW, Robinson SL, Swintek JA, Saari TW, Ankley GT. Editor's Highlight: Sequence Alignment to Predict Across Species Susceptibility (SeqAPASS): A Web-Based Tool for Addressing the Challenges of Cross-Species Extrapolation of Chemical Toxicity. Toxicol Sci. 2016 Oct;153(2):228-45. doi: 10.1093/toxsci/kfw119. Epub 2016 Jun 30. PubMed PMID: 27370413.
17: Bernardi D, Botton M, Andreazza F, Arnaldo Batista Neto E Silva O, João Arioli C, Omoto C. Susceptibility of Bonagota salubricola (Lepidoptera: Tortricidae) to Insecticides in Brazilian Apple Orchards: Implications for Resistance Management. J Econ Entomol. 2016 Aug;109(4):1881-6. doi: 10.1093/jee/tow143. Epub 2016 Jun 24. PubMed PMID: 27341888.
18: Đorđević J, Vladisavljević GT, Trtić-Petrović T. Liquid-phase membrane extraction of targeted pesticides from manufacturing wastewaters in a hollow fibre contactor with feed-stream recycle. Environ Technol. 2017 Jan;38(1):78-84. Epub 2016 Jun 2. PubMed PMID: 27156531.
19: Wing KD. It takes a team: reflections on insecticide discoveries, toxicological problems and enjoying the unexpected. Pest Manag Sci. 2017 Apr;73(4):666-671. doi: 10.1002/ps.4311. Epub 2016 Jun 6. PubMed PMID: 27146911.
20: Rugno GR, Zanardi OZ, Bajonero Cuervo J, de Morais MR, Yamamoto PT. Impact of insect growth regulators on the predator Ceraeochrysa cincta (Schneider) (Neuroptera: Chrysopidae). Ecotoxicology. 2016 Jul;25(5):940-9. doi: 10.1007/s10646-016-1651-9. Epub 2016 Apr 30. PubMed PMID: 27137778.
