WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H527034
CAS#: 881046-01-1
Description: INI-43 is a novel Inhibitor of Nuclear Import-43, showing a significant cytotoxic effect on various cervical and oesophageal cancer cell lines by targeting Kpnß1.
Hodoodo Cat#: H527034
Name: INI-43
CAS#: 881046-01-1
Chemical Formula: C22H23N7
Exact Mass: 385.20
Molecular Weight: 385.475
Elemental Analysis: C, 68.55; H, 6.01; N, 25.44
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Synonym: INI 43; INI43; INI-43
IUPAC/Chemical Name: 3-(1H-Benzimidazol-2-yl)-1-(3-dimethylaminopropyl)pyrrolo[5,4-b]quinoxalin-2-amine
InChi Key: LWPQQQAILAUWTI-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H23N7/c1-28(2)12-7-13-29-20(23)18(21-25-15-9-4-5-10-16(15)26-21)19-22(29)27-17-11-6-3-8-14(17)24-19/h3-6,8-11H,7,12-13,23H2,1-2H3,(H,25,26)
SMILES Code: NC1=C(C2=NC3=CC=CC=C3N2)C4=NC5=CC=CC=C5N=C4N1CCCN(C)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 385.48 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Stelma T, Leaner VD. KPNB1-mediated nuclear import is required for motility and inflammatory transcription factor activity in cervical cancer cells. Oncotarget. 2017 May 16;8(20):32833-32847. doi: 10.18632/oncotarget.15834. PubMed PMID: 28427184; PubMed Central PMCID: PMC5464831.
2: van der Watt PJ, Chi A, Stelma T, Stowell C, Strydom E, Carden S, Angus L, Hadley K, Lang D, Wei W, Birrer MJ, Trent JO, Leaner VD. Targeting the Nuclear Import Receptor Kpnβ1 as an Anticancer Therapeutic. Mol Cancer Ther. 2016 Apr;15(4):560-73. doi: 10.1158/1535-7163.MCT-15-0052. Epub 2016 Feb 1. PubMed PMID: 26832790.