Bifendate

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H527065

CAS#: 73536-69-3

Description: Bifendate is an anti-HBV agent, attenuating hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice.

Chemical Structure

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Bifendate
CAS# 73536-69-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H527065
Name: Bifendate
CAS#: 73536-69-3
Chemical Formula: C20H18O10
Exact Mass: 418.09
Molecular Weight: 418.354
Elemental Analysis: C, 57.42; H, 4.34; O, 38.24

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Bifendate

IUPAC/Chemical Name: Methyl 7-methoxy-4-(7-methoxy-5-methoxycarbonyl-1,3-benzodioxol-4-yl)-1,3-benzodioxole-5-carboxylate

InChi Key: JMZOMFYRADAWOG-UHFFFAOYSA-N

InChi Code: InChI=1S/C20H18O10/c1-23-11-5-9(19(21)25-3)13(17-15(11)27-7-29-17)14-10(20(22)26-4)6-12(24-2)16-18(14)30-8-28-16/h5-6H,7-8H2,1-4H3

SMILES Code: O=C(C1=CC(OC)=C(OCO2)C2=C1C3=C4OCOC4=C(OC)C=C3C(OC)=O)OC

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 418.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Cen J, Guo H, Hong C, Lv J, Yang Y, Wang T, Fang D, Luo W, Wang C. Development of tacrine-bifendate conjugates with improved cholinesterase inhibitory and pro-cognitive efficacy and reduced hepatotoxicity. Eur J Med Chem. 2017 Dec 5;144:128-136. doi: 10.1016/j.ejmech.2017.12.005. [Epub ahead of print] PubMed PMID: 29268129.

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5: Wu F, Zheng H, Yang ZT, Cheng B, Wu JX, Liu XW, Tang CL, Lu SY, Chen ZN, Song FM, Ruan JX, Zhang HY, Liang YH, Song H, Su ZH. Urinary metabonomics study of the hepatoprotective effects of total alkaloids from Corydalis saxicola Bunting on carbon tetrachloride-induced chronic hepatotoxicity in rats using (1)H NMR analysis. J Pharm Biomed Anal. 2017 Jun 5;140:199-209. doi: 10.1016/j.jpba.2017.03.031. Epub 2017 Mar 19. PubMed PMID: 28363136.

6: Xiang H, Han Y, Zhang Y, Yan W, Xu B, Chu F, Xie T, Jia M, Yan M, Zhao R, Wang P, Lei H. A New Oleanolic Acid Derivative against CCl₄-Induced Hepatic Fibrosis in Rats. Int J Mol Sci. 2017 Mar 6;18(3). pii: E553. doi: 10.3390/ijms18030553. PubMed PMID: 28272302; PubMed Central PMCID: PMC5372569.

7: Gu X, Huang Z, Ren Z, Tang X, Xue R, Luo X, Peng S, Peng H, Lu B, Tian J, Zhang Y. Potent Inhibition of Nitric Oxide-Releasing Bifendate Derivatives against Drug-Resistant K562/A02 Cells in Vitro and in Vivo. J Med Chem. 2017 Feb 9;60(3):928-940. doi: 10.1021/acs.jmedchem.6b01075. Epub 2017 Jan 18. PubMed PMID: 28068095.

8: Gao M, Yang J, Wang Z, Yang B, Kuang H, Liu L, Wang L, Yang C. Simultaneous Determination of Purpurin, Munjistin and Mollugin in Rat Plasma by Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry: Application to a Pharmacokinetic Study after Oral Administration of Rubia cordifolia L. Extract. Molecules. 2016 Jun 1;21(6). pii: E717. doi: 10.3390/molecules21060717. PubMed PMID: 27258244.

9: Nie J, Yang D, Hu K, Lu Y. Study on four polymorphs of bifendate based on X-ray crystallography. Acta Pharm Sin B. 2016 May;6(3):234-42. doi: 10.1016/j.apsb.2016.03.006. Epub 2016 Apr 13. PubMed PMID: 27175335; PubMed Central PMCID: PMC4856952.

10: Zou J, Qi F, Ye L, Yao S. Protective Role of Grape Seed Proanthocyanidins Against Ccl4 Induced Acute Liver Injury in Mice. Med Sci Monit. 2016 Mar 17;22:880-9. PubMed PMID: 26986029; PubMed Central PMCID: PMC4801141.

11: Ren Z, Gu X, Lu B, Chen Y, Chen G, Feng J, Lin J, Zhang Y, Peng H. Anticancer efficacy of a nitric oxide-modified derivative of bifendate against multidrug-resistant cancer cells. J Cell Mol Med. 2016 Jun;20(6):1095-105. doi: 10.1111/jcmm.12796. Epub 2016 Feb 10. PubMed PMID: 26864945; PubMed Central PMCID: PMC4882976.

12: Liu X, Liu Y, Cheng M, Xiao H. [Application of ultra high performance liquid chromatography-mass spectrometry to metabolomics study of drug-induced hepatotoxicity]. Se Pu. 2015 Jul;33(7):683-90. Chinese. PubMed PMID: 26672195.

13: Zhang RZ, Qiu H, Wang N, Long FL, Mao DW. Effect of Rheum palmatum L. on NF-κB signaling pathway of mice with acute liver failure. Asian Pac J Trop Med. 2015 Oct;8(10):841-7. doi: 10.1016/j.apjtm.2015.09.011. Epub 2015 Oct 3. PubMed PMID: 26522300.

14: Cai C, Liu M, Li Y, Guo B, Chang H, Zhang X, Yang X, Zhang T. A silica-supported solid dispersion of bifendate using supercritical carbon dioxide method with enhanced dissolution rate and oral bioavailability. Drug Dev Ind Pharm. 2016;42(3):412-7. doi: 10.3109/03639045.2015.1071833. Epub 2015 Jul 29. PubMed PMID: 26219343.

15: Li J, Han L, Ma YF, Huang YF. [Inhibiting effects of three components of Astragalus membranaceus on oxidative stress in Chang Liver cells]. Zhongguo Zhong Yao Za Zhi. 2015 Jan;40(2):318-23. Chinese. PubMed PMID: 26080566.

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18: Wang J, Zhang Y, Liu R, Li X, Cui Y, Qu L. Geniposide protects against acute alcohol-induced liver injury in mice via up-regulating the expression of the main antioxidant enzymes. Can J Physiol Pharmacol. 2015 Apr;93(4):261-7. doi: 10.1139/cjpp-2014-0536. Epub 2015 Mar 2. PubMed PMID: 25730420.

19: Gu X, Ren Z, Peng H, Peng S, Zhang Y. Bifendate-chalcone hybrids: a new class of potential dual inhibitors of P-glycoprotein and breast cancer resistance protein. Biochem Biophys Res Commun. 2014 Dec 12;455(3-4):318-22. doi: 10.1016/j.bbrc.2014.11.016. Epub 2014 Nov 15. PubMed PMID: 25446092.

20: Pu X, Fan W, Yu S, Li Y, Ma X, Liu L, Ren J, Zhang W. Polysaccharides from Angelica and Astragalus exert hepatoprotective effects against carbon-tetrachloride-induced intoxication in mice. Can J Physiol Pharmacol. 2015 Jan;93(1):39-43. doi: 10.1139/cjpp-2014-0331. PubMed PMID: 25415237.