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2-Aminopurine
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WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H527081

CAS#: 452-06-2

Description: 2-Aminopurine is a specific inhibitor of double-stranded RNA-dependent protein kinase, protein kinase R (PKR).

Chemical Structure

2-Aminopurine

CAS# 452-06-2

Instruction

Theoretical Analysis

Hodoodo Cat#: H527081
Name: 2-Aminopurine
CAS#: 452-06-2
Chemical Formula: C5H5N5
Exact Mass: 135.05
Molecular Weight: 135.130
Elemental Analysis: C, 44.44; H, 3.73; N, 51.83

Price and Availability

Size	Price	Availability	Quantity
100mg	USD 270
250mg	USD 450
500mg	USD 820
Bulk inquiry Welcome, Customer: Please do not inquire quote if your intended use is for a patient since our products are for research use and for chemical synthesis use, not for human use . For in-stock products, we listed price in the web page. You may inquire prices for which sizes were not listed. If no price is listed, this means the product is not in stock at the moment, which may be available via custom synthesis. For cost-effective reason, minimum order of 1g is requested (typically very expensive). The lead time is usually 2-4 months. Quote of less than 1g will not be provided. Hodoodo may not offer quote for below reasons: (1) current available synthetic method appears to be extremely expensive which is obviously not affordable to most customers; (2) Key raw material to make the product is temporally not available; (3) DEA controlled substances; (4) the product is under patent protection in customer’s country.

Synonym: 2-Aminopurine

IUPAC/Chemical Name: 7H-Purin-2-ylamine

InChi Key: MWBWWFOAEOYUST-UHFFFAOYSA-N

InChi Code: InChI=1S/C5H5N5/c6-5-7-1-3-4(10-5)9-2-8-3/h1-2H,(H3,6,7,8,9,10)

SMILES Code: NC1=NC=C2NC=NC2=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Instruction:

View handling instruction

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 135.13 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.15 mL	5.76 mL	11.51 mL
5 mM	0.23 mL	1.15 mL	2.3 mL
10 mM	0.12 mL	0.58 mL	1.15 mL
50 mM	0.02 mL	0.12 mL	0.23 mL

Formulation protocol:
In vitro protocol:
In vivo protocol:

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9: Liu Y, Shen T, Li J, Gong H, Chen C, Chen X, Cai C. Ratiometric Fluorescence Sensor for the MicroRNA Determination by Catalyzed Hairpin Assembly. ACS Sens. 2017 Oct 27;2(10):1430-1434. doi: 10.1021/acssensors.7b00313. Epub 2017 Oct 9. PubMed PMID: 28936869.

10: Zhou J, Opoku-Temeng C, Sintim HO. Fluorescent 2-Aminopurine c-di-GMP and GpG Analogs as PDE Probes. Methods Mol Biol. 2017;1657:245-261. doi: 10.1007/978-1-4939-7240-1_19. PubMed PMID: 28889299.

11: Zhang Y, Xiang D, Tang B, Zhang CY. Sensitive Detection of Transcription Factor in Nuclear Extracts by Target-Actuated Isothermal Amplification-Mediated Fluorescence Enhancement. Anal Chem. 2017 Oct 3;89(19):10439-10445. doi: 10.1021/acs.analchem.7b02451. Epub 2017 Sep 21. PubMed PMID: 28845979.

12: Liao R, Li S, Wang H, Chen C, Chen X, Cai C. Simultaneous detection of two hepatocellar carcinoma-related microRNAs using a clever single-labeled fluorescent probe. Anal Chim Acta. 2017 Aug 29;983:181-188. doi: 10.1016/j.aca.2017.06.026. Epub 2017 Jun 20. PubMed PMID: 28811025.

13: Zhou W, Ding J, Liu J. Splitting a DNAzyme enables a Na(+)-dependent FRET signal from the embedded aptamer. Org Biomol Chem. 2017 Aug 23;15(33):6959-6966. doi: 10.1039/c7ob01709j. PubMed PMID: 28792040.

14: Buchanan HS, Pauff SM, Kosmidis TD, Taladriz-Sender A, Rutherford OI, Hatit MZC, Fenner S, Watson AJB, Burley GA. Correction to "Modular, Step-Efficient Palladium-Catalyzed Cross-Coupling Strategy To Access C6-Heteroaryl 2-Aminopurine Ribonucleosides". Org Lett. 2017 Aug 18;19(16):4411. doi: 10.1021/acs.orglett.7b02273. Epub 2017 Aug 2. PubMed PMID: 28766342.

15: Bronson E, McClure M, Sohl J, Wiedner E, Cox S, Latimer EM, Pearson VR, Hayward GS, Fuery A, Ling PD. EPIDEMIOLOGIC EVALUATION OF ELEPHANT ENDOTHELIOTROPIC HERPESVIRUS 3B INFECTION IN AN AFRICAN ELEPHANT (LOXODONTA AFRICANA). J Zoo Wildl Med. 2017 Jun;48(2):335-343. doi: 10.1638/2016-0063R.1. PubMed PMID: 28749266.

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2-Aminopurine featured