Triiodothyronine Sulfate

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H527091

CAS#: 31135-55-4

Description: Triiodothyronine Sulfate is a prodrug to the Conventional Hormone Therapy of Hypothyroidism.


Chemical Structure

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Triiodothyronine Sulfate
CAS# 31135-55-4

Theoretical Analysis

Hodoodo Cat#: H527091
Name: Triiodothyronine Sulfate
CAS#: 31135-55-4
Chemical Formula: C15H11I3NNaO7S
Exact Mass: 752.73
Molecular Weight: 753.016
Elemental Analysis: C, 23.93; H, 1.47; I, 50.56; N, 1.86; Na, 3.05; O, 14.87; S, 4.26

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym: Triiodothyronine Sulfate

IUPAC/Chemical Name: O-[3-Iodo-4-(sulfooxy)phenyl]-3,5-diiodo-l-tyrosine sodium salt

InChi Key: UWRSKBUXXCXAKC-YDALLXLXSA-M

InChi Code: InChI=1S/C15H12I3NO7S.Na/c16-9-6-8(1-2-13(9)26-27(22,23)24)25-14-10(17)3-7(4-11(14)18)5-12(19)15(20)21;/h1-4,6,12H,5,19H2,(H,20,21)(H,22,23,24);/q;+1/p-1/t12-;/m0./s1

SMILES Code: N[C@@H](CC1=CC(I)=C(OC2=CC=C(OS(=O)(O)=O)C(I)=C2)C(I)=C1)C([O-])=O.[Na+]

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 753.02 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Santini F, Giannetti M, Ricco I, Querci G, Saponati G, Bokor D, Rivolta G, Bussi S, Braverman LE, Vitti P, Pinchera A. Steady-State Serum T3 Concentrations for 48 Hours Following the Oral Administration of a Single Dose of 3,5,3'-Triiodothyronine Sulfate (T3S). Endocr Pract. 2014 Jul;20(7):680-9. doi: 10.4158/EP13331.OR. PubMed PMID: 24518178.

2: Wu SY, Polk DH, Huang WS, Ho E, Kattan JM, Fisher DA. 3'-monoiodothyronine sulfate and Triac sulfate are thyroid hormone metabolites in developing sheep. Pediatr Res. 2008 Feb;63(2):149-53. PubMed PMID: 18091342.

3: Wu SY, Polk DH, Huang WS, Fisher DA. Fetal-to-maternal transfer of 3,3',5-triiodothyronine sulfate and its metabolite in sheep. Am J Physiol. 1999 Nov;277(5 Pt 1):E915-9. PubMed PMID: 10567020.

4: Bernus I, Mitchell AM, Manley SW, Mortimer RH. Uptake of L-triiodothyronine sulphate by human choriocarcinoma cell line, JAr. Placenta. 1999 Mar-Apr;20(2-3):161-5. PubMed PMID: 10195736.

5: Santini F, Chiovato L, Ghirri P, Lapi P, Mammoli C, Montanelli L, Scartabelli G, Ceccarini G, Coccoli L, Chopra IJ, Boldrini A, Pinchera A. Serum iodothyronines in the human fetus and the newborn: evidence for an important role of placenta in fetal thyroid hormone homeostasis. J Clin Endocrinol Metab. 1999 Feb;84(2):493-8. PubMed PMID: 10022406.

6: Wu SY, Fisher DA, Huang WS, Beck-Peccoz P, Emerson CH, Kuo SW, Chen WL. Urinary compound W in pregnant women is a potential marker for fetal thyroid function. Am J Obstet Gynecol. 1998 May;178(5):886-91. PubMed PMID: 9609555.

7: Iervasi G, Clerico A, Manfredi C, Sabatino L, Biagini A, Chopra IJ. Acute effects of intravenous amiodarone on sulphate metabolites of thyroid hormones in arrhythmic patients. Clin Endocrinol (Oxf). 1997 Dec;47(6):699-705. PubMed PMID: 9497877.

8: Reinhardt W, Misch C, Jockenhövel F, Wu SY, Chopra I, Philipp T, Reinwein D, Eigler FW, Mann K. Triiodothyronine (T3) reflects renal graft function after renal transplantation. Clin Endocrinol (Oxf). 1997 May;46(5):563-9. PubMed PMID: 9231052.

9: Docter R, Friesema EC, van Stralen PG, Krenning EP, Everts ME, Visser TJ, Hennemann G. Expression of rat liver cell membrane transporters for thyroid hormone in Xenopus laevis oocytes. Endocrinology. 1997 May;138(5):1841-6. PubMed PMID: 9112377.

10: Chopra IJ, Nguyen D. Demonstration of thyromimetic effects of 3,5,3'-triiodothyronine sulfate (T3S) in euthyroid rats. Thyroid. 1996 Jun;6(3):229-32. PubMed PMID: 8837331.

11: Huang WS, Kuo SW, Chen WL, Hsich KS, Wu SY. Maturation of hepatic desulfation activity in developing rats. J Formos Med Assoc. 1996 Jun;95(6):435-9. PubMed PMID: 8772048.

12: Huang WS, Kuo SW, Chen WL, Fuh MM, Wu SY. Increased urinary excretion of sulfated 3,3',5-triiodothyronine in patients with nodular goiters receiving suppressive thyroxine therapy. Thyroid. 1996 Apr;6(2):91-6. PubMed PMID: 8733878.

13: Santini F, Chiovato L, Bartalena L, Lapi P, Palla R, Panichi V, Velluzzi F, Grasso L, Chopra IJ, Martino E, Pinchera A. Study of serum 3,5,3'-triiodothyronine sulfate concentration in patients with systemic non-thyroidal illness. Eur J Endocrinol. 1996 Jan;134(1):45-9. PubMed PMID: 8590953.

14: Visser TJ. Role of sulfate in thyroid hormone sulfation. Eur J Endocrinol. 1996 Jan;134(1):12-4. Review. PubMed PMID: 8590947.

15: Wu SY, Huang WS, Chopra IJ, Jordan M, Alvarez D, Santini F. Sulfation pathway of thyroid hormone metabolism in selenium-deficient male rats. Am J Physiol. 1995 Apr;268(4 Pt 1):E572-9. PubMed PMID: 7733254.

16: Everts ME, Visser TJ, van Buuren JC, Docter R, de Jong M, Krenning EP, Hennemann G. Uptake of triiodothyronine sulfate and suppression of thyrotropin secretion in cultured anterior pituitary cells. Metabolism. 1994 Oct;43(10):1282-6. PubMed PMID: 7934981.

17: Visser TJ. Role of sulfation in thyroid hormone metabolism. Chem Biol Interact. 1994 Jun;92(1-3):293-303. Review. PubMed PMID: 8033262.

18: Polk DH, Reviczky A, Wu SY, Huang WS, Fisher DA. Metabolism of sulfoconjugated thyroid hormone derivatives in developing sheep. Am J Physiol. 1994 Jun;266(6 Pt 1):E892-6. PubMed PMID: 8023919.

19: LoPresti JS, Nicoloff JT. 3,5,3'-Triiodothyronine (T3) sulfate: a major metabolite in T3 metabolism in man. J Clin Endocrinol Metab. 1994 Mar;78(3):688-92. PubMed PMID: 8126143.

20: Wu SY, Polk DH, Huang WS, Reviczky A, Wang K, Fisher DA. Sulfate conjugates of iodothyronines in developing sheep: effect of fetal hypothyroidism. Am J Physiol. 1993 Jul;265(1 Pt 1):E115-20. PubMed PMID: 8338144.