WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561744
CAS#: 76343-93-6
Description: Latrunculin A is a disruptor of microfilament-mediated processes.
Hodoodo Cat#: H561744
Name: Latrunculin A
CAS#: 76343-93-6
Chemical Formula: C22H31NO5S
Exact Mass: 421.19
Molecular Weight: 421.550
Elemental Analysis: C, 62.68; H, 7.41; N, 3.32; O, 18.98; S, 7.61
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: Latrunculin A; Latrunculin-A;
IUPAC/Chemical Name: (R)-4-((1R,4Z,8E,10Z,12S,15R,17R)-17-Hydroxy-5,12-dimethyl-3-oxo-2,16-dioxabicyclo[13.3.1]nonadeca-4,8,10-trien-17-yl)thiazolidin-2-one
InChi Key: DDVBPZROPPMBLW-IZGXTMSKSA-N
InChi Code: InChI=1S/C22H31NO5S/c1-15-7-5-3-4-6-8-16(2)11-20(24)27-18-12-17(10-9-15)28-22(26,13-18)19-14-29-21(25)23-19/h3-5,7,11,15,17-19,26H,6,8-10,12-14H2,1-2H3,(H,23,25)/b4-3+,7-5-,16-11-/t15-,17-,18-,19+,22-/m1/s1
SMILES Code: O=C1SC[C@@H]([C@]2(O)O[C@]3([H])CC[C@H](C)/C=C\C=C\CC/C(C)=C\C(O[C@@](C3)([H])C2)=O)N1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 421.55 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Sanger JW, Wang J, Fan Y, White J, Mi-Mi L, Dube DK, Sanger JM, Pruyne D. Assembly and Maintenance of Myofibrils in Striated Muscle. Handb Exp Pharmacol. 2017;235:39-75. doi: 10.1007/164_2016_53. Review. PubMed PMID: 27832381.
2: Jin T, Xu X, Hereld D. Chemotaxis, chemokine receptors and human disease. Cytokine. 2008 Oct;44(1):1-8. doi: 10.1016/j.cyto.2008.06.017. Epub 2008 Aug 21. Review. PubMed PMID: 18722135; PubMed Central PMCID: PMC2613022.
3: Hickson GR, O'Farrell PH. Anillin: a pivotal organizer of the cytokinetic machinery. Biochem Soc Trans. 2008 Jun;36(Pt 3):439-41. doi: 10.1042/BST0360439. Review. PubMed PMID: 18481976; PubMed Central PMCID: PMC2695931.
4: Kaufman PL. Enhancing trabecular outflow by disrupting the actin cytoskeleton, increasing uveoscleral outflow with prostaglandins, and understanding the pathophysiology of presbyopia interrogating Mother Nature: asking why, asking how, recognizing the signs, following the trail. Exp Eye Res. 2008 Jan;86(1):3-17. Epub 2007 Oct 26. Review. PubMed PMID: 18053986; PubMed Central PMCID: PMC2213279.
5: Ayscough KR. Coupling actin dynamics to the endocytic process in Saccharomyces cerevisiae. Protoplasma. 2005 Oct;226(1-2):81-8. Epub 2005 Oct 20. Review. PubMed PMID: 16231104.