R162
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    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H561746

CAS#: 64302-87-0

Description: R162 is an inhibitor of GDH activity and represses glioma cell growth.

Chemical Structure

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R162
CAS# 64302-87-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H561746
Name: R162
CAS#: 64302-87-0
Chemical Formula: C17H12O3
Exact Mass: 264.08
Molecular Weight: 264.280
Elemental Analysis: C, 77.26; H, 4.58; O, 18.16

Price and Availability

Size Price Availability Quantity
10mg USD 265 2 weeks
25mg USD 480 2 weeks
50mg USD 850 2 Weeks
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Synonym: R162; R 162; R-162;

IUPAC/Chemical Name: 2-Allyl-1-hydroxy-anthraquinone

InChi Key: IMUBGIOLZQTIGI-UHFFFAOYSA-N

InChi Code: InChI=1S/C17H12O3/c1-2-5-10-8-9-13-14(15(10)18)17(20)12-7-4-3-6-11(12)16(13)19/h2-4,6-9,18H,1,5H2

SMILES Code: O=C(C1=C2C=CC=C1)C3=CC=C(CC=C)C(O)=C3C2=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 264.28 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Jin L, Chun J, Pan C, Kumar A, Zhang G, Ha Y, Li D, Alesi GN, Kang Y, Zhou L, Yu WM, Magliocca KR, Khuri FR, Qu CK, Metallo C, Owonikoko TK, Kang S. The PLAG1-GDH1 Axis Promotes Anoikis Resistance and Tumor Metastasis through CamKK2-AMPK Signaling in LKB1-Deficient Lung Cancer. Mol Cell. 2017 Dec 12. pii: S1097-2765(17)30884-5. doi: 10.1016/j.molcel.2017.11.025. [Epub ahead of print] PubMed PMID: 29249655.

2: Cima LN, Colita A, Fica S. Perspectives on the co-treatment with GnRHa in female patients undergoing hematopoietic stem cell transplantation. Endocr Connect. 2017 Nov;6(8):R162-R170. doi: 10.1530/EC-17-0246. Epub 2017 Sep 25. Review. PubMed PMID: 28947558; PubMed Central PMCID: PMC5655684.

3: Gronsang D, Bui AN, Trinh DQ, Bui VN, Nguyen KV, Can MX, Omatsu T, Mizutani T, Nagai M, Katayama Y, Thampaisarn R, Ogawa H, Imai K. Characterization of cross-clade monoclonal antibodies against H5N1 highly pathogenic avian influenza virus and their application to the antigenic analysis of diverse H5 subtype viruses. Arch Virol. 2017 Aug;162(8):2257-2269. doi: 10.1007/s00705-017-3350-0. Epub 2017 Apr 12. PubMed PMID: 28405766.

4: Steffen-Munsberg F, Matzel P, Sowa MA, Berglund P, Bornscheuer UT, Höhne M. Bacillus anthracis ω-amino acid:pyruvate transaminase employs a different mechanism for dual substrate recognition than other amine transaminases. Appl Microbiol Biotechnol. 2016 May;100(10):4511-21. doi: 10.1007/s00253-015-7275-9. Epub 2016 Jan 21. PubMed PMID: 26795966.

5: Akhmanova A, Hoogenraad CC. Microtubule minus-end-targeting proteins. Curr Biol. 2015 Feb 16;25(4):R162-71. doi: 10.1016/j.cub.2014.12.027. Review. PubMed PMID: 25689915.

6: Jin L, Li D, Alesi GN, Fan J, Kang HB, Lu Z, Boggon TJ, Jin P, Yi H, Wright ER, Duong D, Seyfried NT, Egnatchik R, DeBerardinis RJ, Magliocca KR, He C, Arellano ML, Khoury HJ, Shin DM, Khuri FR, Kang S. Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth. Cancer Cell. 2015 Feb 9;27(2):257-70. doi: 10.1016/j.ccell.2014.12.006. PubMed PMID: 25670081; PubMed Central PMCID: PMC4325424.

7: Peat G, Bergknut C, Frobell R, Jöud A, Englund M. Population-wide incidence estimates for soft tissue knee injuries presenting to healthcare in southern Sweden: data from the Skåne Healthcare Register. Arthritis Res Ther. 2014 Jul 31;16(4):R162. doi: 10.1186/ar4678. PubMed PMID: 25082600; PubMed Central PMCID: PMC4262192.

8: Beurskens CJ, Horn J, de Boer AM, Schultz MJ, van Leeuwen EM, Vroom MB, Juffermans NP. Cardiac arrest patients have an impaired immune response, which is not influenced by induced hypothermia. Crit Care. 2014 Jul 30;18(4):R162. doi: 10.1186/cc14002. PubMed PMID: 25078879; PubMed Central PMCID: PMC4261599.

9: Marthiens V, Basto R. Microcephaly: STIL(l) a tale of too many centrosomes. Curr Biol. 2014 Feb 17;24(4):R162-4. doi: 10.1016/j.cub.2013.12.054. PubMed PMID: 24556440.

10: Ten Cate DF, Luime JJ, van der Ven M, Hazes JM, Kooiman K, de Jong N, Bosch JG. Very different performance of the power Doppler modalities of several ultrasound machines ascertained by a microvessel flow phantom. Arthritis Res Ther. 2013 Oct 24;15(5):R162. doi: 10.1186/ar4345. PubMed PMID: 24286540; PubMed Central PMCID: PMC3978434.

11: Xie X, Zhang X, Fu J, Wang H, Jonas JB, Peng X, Tian G, Xian J, Ritch R, Li L, Kang Z, Zhang S, Yang D, Wang N; Beijing iCOP Study Group. Noninvasive intracranial pressure estimation by orbital subarachnoid space measurement: the Beijing Intracranial and Intraocular Pressure (iCOP) study. Crit Care. 2013 Jul 24;17(4):R162. doi: 10.1186/cc12841. PubMed PMID: 23883736; PubMed Central PMCID: PMC4056099.

12: Schultheiß C, Saugel B, Phillip V, Thies P, Noe S, Mayr U, Haller B, Einwächter H, Schmid RM, Huber W. Continuous venovenous hemodialysis with regional citrate anticoagulation in patients with liver failure: a prospective observational study. Crit Care. 2012 Aug 22;16(4):R162. doi: 10.1186/cc11485. PubMed PMID: 22913794; PubMed Central PMCID: PMC3580752.

13: Bjersing JL, Dehlin M, Erlandsson M, Bokarewa MI, Mannerkorpi K. Changes in pain and insulin-like growth factor 1 in fibromyalgia during exercise: the involvement of cerebrospinal inflammatory factors and neuropeptides. Arthritis Res Ther. 2012 Jul 9;14(4):R162. doi: 10.1186/ar3902. PubMed PMID: 22776095; PubMed Central PMCID: PMC3580554.

14: Pinotti M, Caruso P, Canella A, Campioni M, Tagariello G, Castaman G, Giacomelli S, Belvini D, Bernardi F. Ribosome readthrough accounts for secreted full-length factor IX in hemophilia B patients with nonsense mutations. Hum Mutat. 2012 Sep;33(9):1373-6. doi: 10.1002/humu.22120. Epub 2012 Jun 11. PubMed PMID: 22618954.

15: Hsieh AH, Jhou YJ, Liang CT, Chang M, Wang SL. Fragment of tegument protein pp65 of human cytomegalovirus induces autoantibodies in BALB/c mice. Arthritis Res Ther. 2011;13(5):R162. doi: 10.1186/ar3481. Epub 2011 Oct 11. PubMed PMID: 21989080; PubMed Central PMCID: PMC3308095.

16: He JL, Liu JH, Liu F, Tan P, Lin T, Li XL. Mutation screening of BMP4 and Id2 genes in Chinese patients with congenital ureteropelvic junction obstruction. Eur J Pediatr. 2012 Mar;171(3):451-6. doi: 10.1007/s00431-011-1561-z. Epub 2011 Sep 17. PubMed PMID: 21927809.

17: Chantry A. WWP2 ubiquitin ligase and its isoforms: new biological insight and promising disease targets. Cell Cycle. 2011 Aug 1;10(15):2437-9. Epub 2011 Aug 1. PubMed PMID: 21750408; PubMed Central PMCID: PMC4074766.

18: Shahin J, DeVarennes B, Tse CW, Amarica DA, Dial S. The relationship between inotrope exposure, six-hour postoperative physiological variables, hospital mortality and renal dysfunction in patients undergoing cardiac surgery. Crit Care. 2011 Jul 7;15(4):R162. doi: 10.1186/cc10302. PubMed PMID: 21736726; PubMed Central PMCID: PMC3387599.

19: Blumenthal T. Split genes: another surprise from Giardia. Curr Biol. 2011 Feb 22;21(4):R162-3. doi: 10.1016/j.cub.2011.01.032. PubMed PMID: 21334298.

20: Soond SM, Chantry A. Selective targeting of activating and inhibitory Smads by distinct WWP2 ubiquitin ligase isoforms differentially modulates TGFβ signalling and EMT. Oncogene. 2011 May 26;30(21):2451-62. doi: 10.1038/onc.2010.617. Epub 2011 Jan 24. PubMed PMID: 21258410; PubMed Central PMCID: PMC4073228.