WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561755
CAS#: 164204-38-0
Description: Phosphoramidon disodium is a neutral endopeptidase (neprilysin) inhibitor. It blocks degradation of amyloid β peptides and endothelin converting enzyme (ECE).
Hodoodo Cat#: H561755
Name: Phosphoramidon disodium
CAS#: 164204-38-0
Chemical Formula: C23H32N3Na2O10P
Exact Mass: 587.16
Molecular Weight: 587.473
Elemental Analysis: C, 47.02; H, 5.49; N, 7.15; Na, 7.83; O, 27.23; P, 5.27
Synonym: Phosphoramidon disodium;
IUPAC/Chemical Name: sodium (oxido(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)phosphoryl)-L-leucyl-L-tryptophanate
InChi Key: OQKHVXFOYFBMDJ-ODIUWQMJSA-L
InChi Code: InChI=1S/C23H34N3O10P.2Na/c1-11(2)8-16(26-37(33,34)36-23-20(29)19(28)18(27)12(3)35-23)21(30)25-17(22(31)32)9-13-10-24-15-7-5-4-6-14(13)15;;/h4-7,10-12,16-20,23-24,27-29H,8-9H2,1-3H3,(H,25,30)(H,31,32)(H2,26,33,34);;/q;2*+1/p-2/t12-,16-,17-,18-,19+,20+,23-;;/m0../s1
SMILES Code: O[C@H]1[C@H](C)O[C@@H](OP(N[C@@H](CC(C)C)C(N[C@H](C(O[Na])=O)CC2=CNC3=CC=CC=C23)=O)(O[Na])=O)[C@H](O)[C@@H]1O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 587.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Koushik K, Sunkara G, Gwilt P, Kompella UB. Pathways and kinetics of deslorelin degradation in an airway epithelial cell line (Calu-1). Pharm Res. 2003 May;20(5):779-87. PubMed PMID: 12751634.
2: Descombes JJ, Mennecier P, Versluys D, Barou V, de Nanteuil G, Laubie M, Verbeuren TJ. S 17162 is a novel selective inhibitor of big ET-1 responses in the rat. J Cardiovasc Pharmacol. 1995;26 Suppl 3:S61-4. PubMed PMID: 8587469.