Borneol

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H584184

CAS#: 507-70-0

Description: Borneol is a bicyclic organic compound and a terpene derivative.


Chemical Structure

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Borneol
CAS# 507-70-0

Theoretical Analysis

Hodoodo Cat#: H584184
Name: Borneol
CAS#: 507-70-0
Chemical Formula: C10H18O
Exact Mass: 154.14
Molecular Weight: 154.253
Elemental Analysis: C, 77.87; H, 11.76; O, 10.37

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

Request quote for custom synthesis

Synonym:

IUPAC/Chemical Name: Bicyclo(2.2.1)heptan-2-ol, 1,7,7-trimethyl-, (1R,2S,4R)-rel-

InChi Key: DTGKSKDOIYIVQL-WEDXCCLWSA-N

InChi Code: InChI=1S/C10H18O/c1-9(2)7-4-5-10(9,3)8(11)6-7/h7-8,11H,4-6H2,1-3H3/t7-,8+,10+/m1/s1

SMILES Code: O[C@@H]1[C@](C2(C)C)(C)CC[C@]2([H])C1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 154.25 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Zou L, Lin JZ, Hu HL, Wang Y, Wang P, Zhao G, Wang ZG. [Effect of borneol on intestinal absorption of muscone in rats]. Zhongguo Zhong Yao Za Zhi. 2012 Nov;37(22):3490-3. Chinese. PubMed PMID: 23373228.

2: Zhong W, Cui Y, Yu Q, Xie X, Liu Y, Wei M, Ci X, Peng L. Modulation of LPS-stimulated pulmonary inflammation by Borneol in murine acute lung injury model. Inflammation. 2014 Aug;37(4):1148-57. doi: 10.1007/s10753-014-9839-8. PubMed PMID: 24566873.

3: Wu HY, Tang Y, Gao LY, Sun WX, Hua Y, Yang SB, Zhang ZP, Liao GY, Zhou QG, Luo CX, Zhu DY. The synergetic effect of edaravone and borneol in the rat model of ischemic stroke. Eur J Pharmacol. 2014 Oct 5;740:522-31. doi: 10.1016/j.ejphar.2014.06.035. Epub 2014 Jun 27. PubMed PMID: 24975100.

4: Cai Z, Lei X, Lin Z, Zhao J, Wu F, Yang Z, Pu J, Liu Z. Preparation and evaluation of sustained-release solid dispersions co-loading gastrodin with borneol as an oral brain-targeting enhancer. Acta Pharm Sin B. 2014 Feb;4(1):86-93. doi: 10.1016/j.apsb.2013.12.012. Epub 2014 Jan 24. PubMed PMID: 26579369; PubMed Central PMCID: PMC4590720.

5: Xu P, Li Y, Du SY, Lu Y, Bai J, Guo QL. Comparative pharmacokinetics of borneol in cerebral ischemia-reperfusion and sham-operated rats. J Zhejiang Univ Sci B. 2014 Jan;15(1):84-91. doi: 10.1631/jzus.B1300141. PubMed PMID: 24390748; PubMed Central PMCID: PMC3891122.

6: Yin Q, Shi X, Ding H, Dai X, Wan G, Qiao Y. Interactions of borneol with DPPC phospholipid membranes: a molecular dynamics simulation study. Int J Mol Sci. 2014 Nov 6;15(11):20365-81. doi: 10.3390/ijms151120365. PubMed PMID: 25383679; PubMed Central PMCID: PMC4264172.

7: Kong QX, Wu ZY, Chu X, Liang RQ, Xia M, Li L. Study on the anti-cerebral ischemia effect of borneol and its mechanism. Afr J Tradit Complement Altern Med. 2013 Nov 2;11(1):161-4. eCollection 2014. PubMed PMID: 24653571; PubMed Central PMCID: PMC3957259.

8: Jiang J, Shen YY, Li J, Lin YH, Luo CX, Zhu DY. (+)-Borneol alleviates mechanical hyperalgesia in models of chronic inflammatory and neuropathic pain in mice. Eur J Pharmacol. 2015 Jun 15;757:53-8. doi: 10.1016/j.ejphar.2015.03.056. Epub 2015 Mar 31. PubMed PMID: 25835611.

9: Chen Z, Gong X, Lu Y, Du S, Yang Z, Bai J, Li P, Wu H. Enhancing effect of borneol and muscone on geniposide transport across the human nasal epithelial cell monolayer. PLoS One. 2014 Jul 3;9(7):e101414. doi: 10.1371/journal.pone.0101414. eCollection 2014. PubMed PMID: 24992195; PubMed Central PMCID: PMC4081582.

10: Chen ZZ, Du SY, Lu Y, Xu P, Yang B, Liu HM. [Mechanism research of aromatics borneol and muscone]. Zhong Yao Cai. 2014 Mar;37(3):460-4. Chinese. PubMed PMID: 25174113.

11: Song X, Lu Y, Wen R, Du S, Zhao X, Zhao J, Li Y. In situ and in vivo study of nasal absorption of borneol in rats. Pharmazie. 2012 Oct;67(10):848-51. PubMed PMID: 23136719.

12: Zhang L, Han L, Qin J, Lu W, Wang J. The use of borneol as an enhancer for targeting aprotinin-conjugated PEG-PLGA nanoparticles to the brain. Pharm Res. 2013 Oct;30(10):2560-72. doi: 10.1007/s11095-013-1055-y. Epub 2013 Apr 25. PubMed PMID: 23615859.

13: Xin HL, He XR, Li W, Zhou ZD, Zhang S, Wang GJ. The effect of borneol on the concentration of meropenem in rat brain and blood. J Asian Nat Prod Res. 2014;16(6):648-57. doi: 10.1080/10286020.2014.916282. Epub 2014 May 14. PubMed PMID: 24827508.

14: Sherkheli MA, Schreiner B, Haq R, Werner M, Hatt H. Borneol inhibits TRPA1, a proinflammatory and noxious pain-sensing cation channel. Pak J Pharm Sci. 2015 Jul;28(4):1357-63. PubMed PMID: 26142526.

15: Machado M, Dinis AM, Santos-Rosa M, Alves V, Salgueiro L, Cavaleiro C, Sousa MC. Activity of Thymus capitellatus volatile extract, 1,8-cineole and borneol against Leishmania species. Vet Parasitol. 2014 Feb 24;200(1-2):39-49. doi: 10.1016/j.vetpar.2013.11.016. Epub 2013 Nov 26. PubMed PMID: 24365244.

16: Zhao JY, Du SY, Lu Y, Wu HC, Li HY. [Study on tissue distribution of borneol in mice by intravenous and intranasal administrations]. Zhongguo Zhong Yao Za Zhi. 2013 Apr;38(7):1071-4. Chinese. PubMed PMID: 23847960.

17: Almeida JR, Souza GR, Silva JC, Saraiva SR, Júnior RG, Quintans Jde S, Barreto Rde S, Bonjardim LR, Cavalcanti SC, Quintans LJ Jr. Borneol, a bicyclic monoterpene alcohol, reduces nociceptive behavior and inflammatory response in mice. ScientificWorldJournal. 2013 Apr 18;2013:808460. doi: 10.1155/2013/808460. Print 2013. PubMed PMID: 23710149; PubMed Central PMCID: PMC3654274.

18: Huang L, Bai J, Yang H, Liu J, Cui H. Combined use of borneol or menthol with labrasol promotes penetration of baicalin through rabbit cornea in vitro. Pak J Pharm Sci. 2015 Jan;28(1):1-7. PubMed PMID: 25553687.

19: Silva-Filho JC, Oliveira NN, Arcanjo DD, Quintans-Júnior LJ, Cavalcanti SC, Santos MR, Oliveira Rde C, Oliveira AP. Investigation of mechanisms involved in (-)-borneol-induced vasorelaxant response on rat thoracic aorta. Basic Clin Pharmacol Toxicol. 2012 Feb;110(2):171-7. doi: 10.1111/j.1742-7843.2011.00784.x. Epub 2011 Sep 28. PubMed PMID: 21883938.

20: Ren J, Zou M, Gao P, Wang Y, Cheng G. Tissue distribution of borneol-modified ganciclovir-loaded solid lipid nanoparticles in mice after intravenous administration. Eur J Pharm Biopharm. 2013 Feb;83(2):141-8. doi: 10.1016/j.ejpb.2012.10.018. Epub 2012 Nov 29. PubMed PMID: 23201052.