WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H527530
CAS#: 430458-66-5
Description: MMRi64 is a novel specific inhibitor of Mdm2-MdmX E3 ligase activity toward Mdm2 and p53 substrates, potently inducing p53-dependent and p53-independent apoptosis in lymphoma cells.
Hodoodo Cat#: H527530
Name: MMRi64
CAS#: 430458-66-5
Chemical Formula: C22H17Cl2N3O
Exact Mass: 409.07
Molecular Weight: 410.298
Elemental Analysis: C, 64.40; H, 4.18; Cl, 17.28; N, 10.24; O, 3.90
Synonym: MMRi64; MMRi-64; MMRi 64;
IUPAC/Chemical Name: 7-[(2,3-Dichloro-phenyl)-(4-methyl-pyridin-2-ylamino)-methyl]-quinolin-8-ol
InChi Key: HQICAVDTVBACIN-UHFFFAOYSA-N
InChi Code: InChI=1S/C22H17Cl2N3O/c1-13-9-11-25-18(12-13)27-21(15-5-2-6-17(23)19(15)24)16-8-7-14-4-3-10-26-20(14)22(16)28/h2-12,21,28H,1H3,(H,25,27)
SMILES Code: OC1=C2N=CC=CC2=CC=C1C(C3=CC=CC(Cl)=C3Cl)NC4=NC=CC(C)=C4
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
| Biological target: | |
| In vitro activity: | |
| In vivo activity: |
The following data is based on the product molecular weight 410.30 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Wu W, Xu C, Ling X, Fan C, Buckley BP, Chernov MV, Ellis L, Li F, Muñoz IG, Wang X. Targeting RING domains of Mdm2-MdmX E3 complex activates apoptotic arm of the p53 pathway in leukemia/lymphoma cells. Cell Death Dis. 2015 Dec 31;6:e2035. doi: 10.1038/cddis.2015.358. PubMed PMID: 26720344; PubMed Central PMCID: PMC4720891.
