WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561819
CAS#: 33985-68-1
Description: DIM-C-pPhOCH3 is a Nur77 agonist. It has been shown to induce apoptosis in cancer cell lines and long-term potentiation in hippocampal slices and long-term contextual fear memory in an in vivo mouse mode.
Hodoodo Cat#: H561819
Name: DIM-C-pPhOCH3
CAS#: 33985-68-1
Chemical Formula: C24H20N2O
Exact Mass: 352.16
Molecular Weight: 352.437
Elemental Analysis: C, 81.79; H, 5.72; N, 7.95; O, 4.54
Synonym: DIM-C-pPhOCH3; DIM C pPhOCH3; DIM-C-pPhOMe; DIM C pPhOMe;
IUPAC/Chemical Name: 3,3'-((4-methoxyphenyl)methylene)bis(1H-indole)
InChi Key: ZCCMKJAXOIFTHH-UHFFFAOYSA-N
InChi Code: InChI=1S/C24H20N2O/c1-27-17-12-10-16(11-13-17)24(20-14-25-22-8-4-2-6-18(20)22)21-15-26-23-9-5-3-7-19(21)23/h2-15,24-26H,1H3
SMILES Code: COC1=CC=C(C(C2=CNC3=C2C=CC=C3)C4=CNC5=C4C=CC=C5)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 352.44 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Cho SD, Lei P, Abdelrahim M, Yoon K, Liu S, Guo J, Papineni S, Chintharlapalli S, Safe S. 1,1-bis(3'-indolyl)-1-(p-methoxyphenyl)methane activates Nur77-independent proapoptotic responses in colon cancer cells. Mol Carcinog. 2008 Apr;47(4):252-63. PubMed PMID: 17957723.