WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H527656
CAS#: 917877-86-2
Description: Bisdionin F is a selective hAMCase Inhibitor.
Hodoodo Cat#: H527656
Name: Bisdionin F
CAS#: 917877-86-2
Chemical Formula: C16H18N8O4
Exact Mass: 386.15
Molecular Weight: 386.372
Elemental Analysis: C, 49.74; H, 4.70; N, 29.00; O, 16.56
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Synonym: Bisdionin F
IUPAC/Chemical Name: 3,7-Dimethyl-1-[3-(3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-purin-1-yl)-propyl]-3,7-dihydro-purine-2,6-dione
InChi Key: PUHJHZQYIBJCSQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C16H18N8O4/c1-20-8-19-12-10(20)14(26)24(16(28)22(12)3)6-4-5-23-13(25)9-11(18-7-17-9)21(2)15(23)27/h7-8H,4-6H2,1-3H3,(H,17,18)
SMILES Code: O=C(N1CCCN2C(N(C)C3=C(NC=N3)C2=O)=O)N(C)C4=C(N(C)C=N4)C1=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 386.37 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Wagener J, MacCallum DM, Brown GD, Gow NA. Candida albicans Chitin Increases Arginase-1 Activity in Human Macrophages, with an Impact on Macrophage Antimicrobial Functions. MBio. 2017 Jan 24;8(1). pii: e01820-16. doi: 10.1128/mBio.01820-16. PubMed PMID: 28119468; PubMed Central PMCID: PMC5263244.
2: Sutherland TE, Andersen OA, Betou M, Eggleston IM, Maizels RM, van Aalten D, Allen JE. Analyzing airway inflammation with chemical biology: dissection of acidic mammalian chitinase function with a selective drug-like inhibitor. Chem Biol. 2011 May 27;18(5):569-79. doi: 10.1016/j.chembiol.2011.02.017. PubMed PMID: 21609838; PubMed Central PMCID: PMC3115046.