Mosedipimod

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H561855

CAS#: 221139-79-3

Description: Mosedipimod, also known as EC-18, is an immunomodulator, anti-inflammatory drug candidate. Mosedipimod is a synthetic version of a monoacetyldiacylglyceride naturally occurring in various seed oils, bovine udder and milk fat, antlers of sika deer, with potential antineoplastic activity. Mosedipimod stimulates calcium influx into T lymphocytes and increases the production of various cytokines, including interleukin (IL) -2, IL-4, IL-12, interferon-gamma (IFN-g), and granulocyte-macrophage colony-stimulating factor (GM-CSF). This stimulates the proliferation of hematopoietic stem cells, bone marrow stromal cells and immune cells, including T and B lymphocytes, dendritic cells (DCs) and macrophages. Therefore, mosedipimod may stimulate the immune system to target cancer cells. In addition, mosedipimod enhances the cytolytic activity of natural killer (NK) cells and suppresses the expression of the transmembrane protein tumor cell toll-like receptor 4 (TLR-4) on cancer cells. As activation of TLR-4 enhances immunosuppression and stimulates cancer cell growth, blocking TLR-4 expression suppresses tumor cell proliferation.


Chemical Structure

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Mosedipimod
CAS# 221139-79-3

Theoretical Analysis

Hodoodo Cat#: H561855
Name: Mosedipimod
CAS#: 221139-79-3
Chemical Formula: C39H70O6
Exact Mass: 634.52
Molecular Weight: 634.980
Elemental Analysis: C, 73.77; H, 11.11; O, 15.12

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Mosedipimod; EC18; EC-18; EC 18; 1-Palmitoyl-2-linoleoyl-3-acetylglycerol;

IUPAC/Chemical Name: (R)-1-acetoxy-3-(palmitoyloxy)propan-2-yl (9Z,12Z)-octadeca-9,12-dienoate

InChi Key: GAKUNXBDVGLOFS-WCCXBCNRSA-N

InChi Code: InChI=1S/C39H70O6/c1-4-6-8-10-12-14-16-18-19-21-23-25-27-29-31-33-39(42)45-37(34-43-36(3)40)35-44-38(41)32-30-28-26-24-22-20-17-15-13-11-9-7-5-2/h12,14,18-19,37H,4-11,13,15-17,20-35H2,1-3H3/b14-12-,19-18-/t37-/m1/s1

SMILES Code: O=C(O[C@@H](COC(CCCCCCCCCCCCCCC)=O)COC(C)=O)CCCCCCC/C=C\C/C=C\CCCCC

Appearance: Liquid

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 634.98 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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