WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H561874
CAS#: 88903-69-9
Description: Xestospongin C is a selective, reversible and membrane-permeable inhibitor of IP3 receptor.
Hodoodo Cat#: H561874
Name: Xestospongin C
CAS#: 88903-69-9
Chemical Formula: C28H50N2O2
Exact Mass: 446.39
Molecular Weight: 446.720
Elemental Analysis: C, 75.28; H, 11.28; N, 6.27; O, 7.16
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Synonym: Xestospongin C; Xestospongin-C;
IUPAC/Chemical Name: [1R-(1R,4aR,11R,12aS,13S,16aS,23R,24aS)]-eicosahydro-5H,17H-1,23:11,13-diethano-2H,14H-[1,11]dioxacycloeicosino[2,3-b:12,13-b1]dipyridine
InChi Key: PQYOPBRFUUEHRC-MUJQFDPKSA-N
InChi Code: InChI=1S/C28H50N2O2/c1-3-7-15-25-17-21-30-20-10-14-24(28(30)31-25)12-6-2-4-8-16-26-18-22-29-19-9-13-23(11-5-1)27(29)32-26/h23-28H,1-22H2/t23-,24+,25-,26-,27+,28+/m0/s1
SMILES Code: N12CCC[C@@H](CCCCCC[C@@H]3O[C@H]([C@@H]4CCC5)N5CC3)[C@H]1O[C@@H](CCCCCC4)CC2
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 446.72 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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2: Peng L, Li B, Du T, Wang F, Hertz L. Does conventional anti-bipolar and antidepressant drug therapy reduce NMDA-mediated neuronal excitation by downregulating astrocytic GluK2 function? Pharmacol Biochem Behav. 2012 Feb;100(4):712-25. doi: 10.1016/j.pbb.2011.03.021. Epub 2011 Apr 2. Review. PubMed PMID: 21463649.
3: Parry H, McDougall A, Whitaker M. Endoplasmic reticulum generates calcium signalling microdomains around the nucleus and spindle in syncytial Drosophila embryos. Biochem Soc Trans. 2006 Jun;34(Pt 3):385-8. Review. PubMed PMID: 16709168.