cp028
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Hodoodo CAT#: H561876

CAS#: 347397-83-5

Description: cp028 is an inhibitor of pre-mRNA splicing in vitro.

Chemical Structure

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cp028
CAS# 347397-83-5
Instruction

Theoretical Analysis

Hodoodo Cat#: H561876
Name: cp028
CAS#: 347397-83-5
Chemical Formula: C23H17FN2O4
Exact Mass: 404.12
Molecular Weight: 404.390
Elemental Analysis: C, 68.31; H, 4.24; F, 4.70; N, 6.93; O, 15.83

Price and Availability

Size Price Availability Quantity
5mg USD 850 2 Weeks
10mg USD 1450 2 Weeks
25mg USD 2950 2 Weeks
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Synonym: cp028; cp-028; cp 028; Compound 028; Compound-028; Compound028;

IUPAC/Chemical Name: 1-(2-Ethylphenyl)-5-((5-(4-fluorophenyl)furan-2-yl)methylene) pyrimidine-2,4,6 (1H,3H,5H)-trione

InChi Key: KKBJKSJVJPXCRA-QGOAFFKASA-N

InChi Code: InChI=1S/C23H17FN2O4/c1-2-14-5-3-4-6-19(14)26-22(28)18(21(27)25-23(26)29)13-17-11-12-20(30-17)15-7-9-16(24)10-8-15/h3-13H,2H2,1H3,(H,25,27,29)/b18-13+

SMILES Code: O=C1NC(/C(C(N1C2=CC=CC=C2CC)=O)=C\C3=CC=C(C4=CC=C(F)C=C4)O3)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 404.39 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Sidarovich A, Will CL, Anokhina MM, Ceballos J, Sievers S, Agafonov DE, Samatov T, Bao P, Kastner B, Urlaub H, Waldmann H, Lührmann R. Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation. Elife. 2017 Mar 16;6. pii: e23533. doi: 10.7554/eLife.23533. PubMed PMID: 28300534; PubMed Central PMCID: PMC5354520.