Brocrinat

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Hodoodo CAT#: H584271

CAS#: 72481-99-3

Description: Brocrinat, also known as HP 522, is an active saluretic and has at least one site of action in the medullary ascending limb of Henle's loop; N1 from CA Vol 92 Form Index.

Chemical Structure

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Brocrinat
CAS# 72481-99-3
Instruction

Theoretical Analysis

Hodoodo Cat#: H584271
Name: Brocrinat
CAS#: 72481-99-3
Chemical Formula: C15H9BrFNO4
Exact Mass: 364.97
Molecular Weight: 366.142
Elemental Analysis: C, 49.21; H, 2.48; Br, 21.82; F, 5.19; N, 3.83; O, 17.48

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: Brocrinat; HP 522;

IUPAC/Chemical Name: Acetic acid, ((7-bromo-3-(2-fluorophenyl)-1,2-benzisoxazol-6-yl)oxy)-

InChi Key: QWOLGQYXAQSNAE-UHFFFAOYSA-N

InChi Code: InChI=1S/C15H9BrFNO4/c16-13-11(21-7-12(19)20)6-5-9-14(18-22-15(9)13)8-3-1-2-4-10(8)17/h1-6H,7H2,(H,19,20)

SMILES Code: O=C(O)COC1=C(Br)C2=C(C=C1)C(C3=CC=CC=C3F)=NO2

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 366.14 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Kitzen JM, Schwenkler MA, Bixby PR, Wilson SJ, Shutske G, Setescak L, Allen R, Rosenblum I. Characterization of the renal pharmacology of HP-522, a loop diuretic with uricosuric activity. Life Sci. 1980 Dec 22-29;27(25-26):2547-52. PubMed PMID: 7219027.

2: Shutske GM, Setescak LL, Allen RC, Davis L, Effland RC, Ranbom K, Kitzen JM, Wilker JC, Novick WJ Jr. [(3-aryl-1,2-benzisoxazol-6-yl)oxy]acetic acids. A new diuretic series. J Med Chem. 1982 Jan;25(1):36-44. PubMed PMID: 7086820.