CM-TPMF

    WARNING: This product is for research use only, not for human or veterinary use.

Hodoodo CAT#: H561886

CAS#: 477865-59-1 (racemic)

Description: CM-TPMF is a subtype-selective activator of K(Ca)2.1. The K(Ca)2.1 selectivity of (-)-CM-TPMF depends critically on Ser293 as revealed by loss- and gain-of-function mutations.

Chemical Structure

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CM-TPMF
CAS# 477865-59-1 (racemic)
Instruction

Theoretical Analysis

Hodoodo Cat#: H561886
Name: CM-TPMF
CAS#: 477865-59-1 (racemic)
Chemical Formula: C16H17ClN6O2
Exact Mass: 360.11
Molecular Weight: 360.800
Elemental Analysis: C, 53.26; H, 4.75; Cl, 9.83; N, 23.29; O, 8.87

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Synonym: CM-TPMF; CM TPMF; CMTPMF;

IUPAC/Chemical Name: (S,E)-N-(7-(1-(4-chloro-2-methylphenoxy)ethyl)-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)-N'-methoxyformimidamide

InChi Key: OZWWQEQUDKBSCF-NSHDSACASA-N

InChi Code: InChI=1S/C16H17ClN6O2/c1-10-8-12(17)4-5-14(10)25-11(2)13-6-7-18-16-21-15(22-23(13)16)19-9-20-24-3/h4-9,11H,1-3H3,(H,19,20,22)/t11-/m0/s1

SMILES Code: CO/N=C/NC1=NN2C([C@@H](OC3=CC=C(Cl)C=C3C)C)=CC=NC2=N1

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 360.80 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Hougaard C, Hammami S, Eriksen BL, Sørensen US, Jensen ML, Strøbæk D, Christophersen P. Evidence for a common pharmacological interaction site on K(Ca)2 channels providing both selective activation and selective inhibition of the human K(Ca)2.1 subtype. Mol Pharmacol. 2012 Feb;81(2):210-9. doi: 10.1124/mol.111.074252. Epub 2011 Nov 1. PubMed PMID: 22046005.