WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H407875
CAS#: 2132410-88-7
Description: QD325 is a potent redox modulator for the Treatment of Pancreatic Ductal Adenocarcinoma. QD325 can induce substantial reactive oxygen species (ROS) in PDAC cells. Nascent RNA sequencing following treatments with QD325 revealed induction of stress responses in nucleus, endoplasmic reticulum, and mitochondria of pancreatic cancer cells. Furthermore, QD325 induced Nrf2-mediated oxidative stress and unfolded protein responses as demonstrated by dose dependent increases in RNA synthesis of representative genes such as NQO1, HMOX1, DDIT3 and HSPA5. QD325 is as a new therapeutic in the treatment of PDAC.
Hodoodo Cat#: H407875
Name: QD325
CAS#: 2132410-88-7
Chemical Formula: C20H13N3O2
Exact Mass: 327.10
Molecular Weight: 327.343
Elemental Analysis: C, 73.38; H, 4.00; N, 12.84; O, 9.78
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Synonym: QD325; QD-325; QD 325.
IUPAC/Chemical Name: 6-([1,1′-Biphenyl]-4-ylamino)quinazoline-5,8-dione
InChi Key: YOULFPRRTVALHQ-UHFFFAOYSA-N
InChi Code: InChI=1S/C20H13N3O2/c24-18-10-17(20(25)16-11-21-12-22-19(16)18)23-15-8-6-14(7-9-15)13-4-2-1-3-5-13/h1-12,23H
SMILES Code: O=C1C(NC2=CC=C(C3=CC=CC=C3)C=C2)=CC(C4=NC=NC=C41)=O
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info: Altering redox homeostasis provides distinctive therapeutic opportunities for the treatment of pancreatic cancer. Quinazolinediones (QDs) are novel redox modulators that we previously showed to induce potent growth inhibition in pancreatic ductal adenocarcinoma (PDAC) cell lines.
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The following data is based on the product molecular weight 327.34 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
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1: Kuang Y, Sechi M, Nurra S, Ljungman M, Neamati N. Design and Synthesis of
Novel Reactive Oxygen Species Inducers for the Treatment of Pancreatic Ductal
Adenocarcinoma. J Med Chem. 2018 Jan 12. doi: 10.1021/acs.jmedchem.7b01463. [Epub
ahead of print] PubMed PMID: 29328656.
