WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H341018
CAS#: 63250-48-6
Description: Piprozoline(or piprozolin) is a medication for bile therapy.
Hodoodo Cat#: H341018
Name: Piprozoline
CAS#: 63250-48-6
Chemical Formula: C14H22N2O3S
Exact Mass: 298.14
Molecular Weight: 298.401
Elemental Analysis: C, 56.35; H, 7.43; N, 9.39; O, 16.08; S, 10.74
This product is not in stock, which may be available by custom synthesis.
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Synonym: Piprozoline; piprozolin.
IUPAC/Chemical Name: delta(sup 2,alpha)-Thiazolidineacetic acid, 3-ethyl-4-oxo-5-piperidino-, ethyl ester, (Z)-
InChi Key: UAXYBJSAPFTPNB-BMSUMIBZSA-N
InChi Code: InChI=1S/C14H22N2O3S/c1-3-16-11(10-12(17)19-4-2)20-14(13(16)18)15-8-6-5-7-9-15/h10,14H,3-9H2,1-2H3/b11-10-/t14-/m0/s1
SMILES Code: C(\C=C1/S[C@@H](C(N1CC)=O)N1CCCCC1)(=O)OCC
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 298.40 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Chankvetadze B. Enantioseparation in capillary chromatography and capillary electrochromatography using polysaccharide-type chiral stationary phases. Methods Mol Biol. 2004;243:387-399. PubMed PMID: 14970638.
2: Tiscornia OM, Cresta MA, Tumilasci O, Waisman H. [Hydroelactic and ecbolic of piprozoline on basal bile-pancreatic secretion in rats]. Acta Gastroenterol Latinoam. 1984;14(1):13-25. Spanish. PubMed PMID: 6524268.
3: Satzinger G. [Structure-activity relationships of etozolin, a novel diuretic (author's transl)]. Arzneimittelforschung. 1977;27(9a):1742-45. German. PubMed PMID: 578762.
4: Friedrich G, Vollmer KO. [Studies on the influence of piprozoline on the microsomal enzyme system of the rat liver (author's transl)]. Arzneimittelforschung. 1977;27(2b):517-9. German. PubMed PMID: 577415.
5: Gladigau V, Ehret I. [Metabolism and pharmacokinetics of piprozoline in rat, dog and man. 3rd communication: Determination of piprozoline and metabolite I in plasma and urine (author's transl)]. Arzneimittelforschung. 1977;27(2b):512-6. German. PubMed PMID: 577414.
6: Hodenberg AV, Klemisch W, Vollmer KO. [Metabolism and pharmacokinetics of piprozoline in rat, dog and man. 2nd Communication: Determination of metabolic profiles with the aid of an HPLC-radioactivity detection system following direct injection of urine and bile onto a reversed-phase column (author's transl)]. Arzneimittelforschung. 1977;27(2b):508-11. German. PubMed PMID: 577413.
7: Vollmer KO, Hodenberg AV, Poisson A, Bode R, Schauerte E. [Metabolism and pharmacokinetics of piprozoline in the rat, dog and man. 1. Studies with the radioactively-labeled substance]. Arzneimittelforschung. 1977;27(2b):502-8. German. PubMed PMID: 577412.
8: Gladigau V, Ehret I, Hengy H. [TLC-method for quantitative densitometric determination of piprozoline and its main metabolite using internal standards (author's transl)]. Arzneimittelforschung. 1977;27(2b):499-502. German. PubMed PMID: 577411.
9: Wiegleb J, Herrmann M, Leuschner F. [Toxicological study on piprozoline (author's transl)]. Arzneimittelforschung. 1977;27(2b):493-9. German. PubMed PMID: 577410.
10: Tauschel HD, Hermann M. [Pharmacological effect of piprozoline on the exocrine pancreas of dogs (author's transl)]. Arzneimittelforschung. 1977;27(2b):489-93. German. PubMed PMID: 577409.
11: Tauschel HD, Herrmann M. [Pharmacological effects of piprozoline on bile secretion in dogs (author's transl)]. Arzneimittelforschung. 1977;27(2b):480-8. German. PubMed PMID: 577408.
12: Herrmann M, Bierkenmayer E, Ganser V, Heldt W, Steinbrecher W. [On the pharmacology of piprozoline (author's transl)]. Arzneimittelforschung. 1977;27(2b):467-75. German. PubMed PMID: 577406.
13: Satzinger G. [2-Carbethoxymethylene-thiazolidones-(4), a novel series of Heterocycles with choleretic properties]. Arzneimittelforschung. 1977;27(2b):463-6. German. PubMed PMID: 577405.
14: Schleicher E. [Piprozoline in clinical trials (author's transl)]. Arzneimittelforschung. 1977;27(2b):520-6. German. PubMed PMID: 326261.