WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H341023
CAS#: 72402-20-1
Description: Z-10-Hydroxyamitriptyline
Hodoodo Cat#: H341023
Name: Z-10-Hydroxyamitriptyline
CAS#: 72402-20-1
Chemical Formula: C20H23NO
Exact Mass: 293.18
Molecular Weight: 293.410
Elemental Analysis: C, 81.87; H, 7.90; N, 4.77; O, 5.45
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Synonym: Z-10-Hydroxyamitriptyline
IUPAC/Chemical Name: 5H-Dibenzo(a,d)cyclohepten-10-ol, 5-(3-(dimethylamino)propylidene)-10,11-dihydro-, (Z)-
InChi Key: GHWBJXOKAFHZAI-ATVHPVEESA-N
InChi Code: InChI=1S/C20H23NO/c1-21(2)13-7-12-17-16-9-4-3-8-15(16)14-20(22)19-11-6-5-10-18(17)19/h3-6,8-12,20,22H,7,13-14H2,1-2H3/b17-12-
SMILES Code: CN(C)CC\C=C/1\c2ccccc2CC(O)c3ccccc13
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 293.41 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Shimoda K, Yasuda S, Morita S, Shibasaki M, Someya T, Bertilsson L, Takahashi S. Significance of monitoring plasma levels of amitriptyline, and its hydroxylated and desmethylated metabolites in prediction of the clinical outcome of depressive state. Psychiatry Clin Neurosci. 1997 Feb;51(1):35-41. PubMed PMID: 9076859.
2: Ulrich S, Isensee T, Pester U. Simultaneous determination of amitriptyline, nortriptyline and four hydroxylated metabolites in serum by capillary gas-liquid chromatography with nitrogen-phosphorus-selective detection. J Chromatogr B Biomed Appl. 1996 Oct 11;685(1):81-9. PubMed PMID: 8930756.
3: Breyer-Pfaff U, Becher B, Nusser E, Nill K, Baier-Weber B, Zaunbrecher D, Wachsmuth H, Prox A. Quaternary N-glucuronides of 10-hydroxylated amitriptyline metabolites in human urine. Xenobiotica. 1990 Jul;20(7):727-38. PubMed PMID: 2238706.
4: Nusser E, Nill K, Breyer-Pfaff U. Enantiomer analysis of E- and Z-10-hydroxyamitriptyline in human urine. J Chromatogr. 1990 Jun 8;528(1):163-71. PubMed PMID: 2384550.
5: Edelbroek PM, Zitman FG, Schreuder JN, Rooymans HG, de Wolff FA. Amitriptyline metabolism in relation to antidepressive effect. Clin Pharmacol Ther. 1984 Apr;35(4):467-73. PubMed PMID: 6705444.