WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562067
CAS#: 1448419-13-3
Description: PDE5-IN-6c is a potent and selective PDE5A1 inhibitor.
Hodoodo Cat#: H562067
Name: PDE5-IN-6c
CAS#: 1448419-13-3
Chemical Formula: C23H21ClN4O2
Exact Mass: 420.14
Molecular Weight: 420.890
Elemental Analysis: C, 65.63; H, 5.03; Cl, 8.42; N, 13.31; O, 7.60
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Synonym: PDE5-IN-6c; PDE5 IN 6c; PDE5IN6c; PDE5 inhibitor 6c;
IUPAC/Chemical Name: 2-Acetyl-10-((3-chloro-4-methoxybenzyl)amino)-1,2,3,4-tetrahydrobenzo[b][1,6]naphthyridine-8-carbonitrile
InChi Key: YLBRHUHHQIYMSH-UHFFFAOYSA-N
InChi Code: InChI=1S/C23H21ClN4O2/c1-14(29)28-8-7-21-18(13-28)23(17-9-15(11-25)3-5-20(17)27-21)26-12-16-4-6-22(30-2)19(24)10-16/h3-6,9-10H,7-8,12-13H2,1-2H3,(H,26,27)
SMILES Code: N#CC1=CC=C2N=C3CCN(C(C)=O)CC3=C(NCC4=CC=C(OC)C(Cl)=C4)C2=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 420.89 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Fiorito J, Vendome J, Saeed F, Staniszewski A, Zhang H, Yan S, Deng SX, Arancio O, Landry DW. Identification of a Novel 1,2,3,4-Tetrahydrobenzo[b][1,6]naphthyridine Analogue as a Potent Phosphodiesterase 5 Inhibitor with Improved Aqueous Solubility for the Treatment of Alzheimer's Disease. J Med Chem. 2017 Nov 9;60(21):8858-8875. doi: 10.1021/acs.jmedchem.7b00979. Epub 2017 Oct 23. PubMed PMID: 28985058.
2: Sasseville M, Côté N, Gagnon MC, Richard FJ. Up-regulation of 3'5'-cyclic guanosine monophosphate-specific phosphodiesterase in the porcine cumulus-oocyte complex affects steroidogenesis during in vitro maturation. Endocrinology. 2008 Nov;149(11):5568-76. doi: 10.1210/en.2008-0547. Epub 2008 Jul 31. PubMed PMID: 18669600.
3: Kim DK, Lee N, Lee JY, Ryu DH, Kim JS, Lee SH, Choi JY, Chang K, Kim YW, Im GJ, Choi WS, Kim TK, Ryu JH, Kim NH, Lee K. Synthesis and phosphodiesterase 5 inhibitory activity of novel phenyl ring modified sildenafil analogues. Bioorg Med Chem. 2001 Jun;9(6):1609-16. PubMed PMID: 11408180.