WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562095
CAS#: 1346526-26-8
Description: Sibiriline is an inhibitor of Receptor-Interacting Protein Kinase 1 (RIPK1). It acts by preventing immune-dependent hepatitis.
Hodoodo Cat#: H562095
Name: Sibiriline
CAS#: 1346526-26-8
Chemical Formula: C13H10N2O
Exact Mass: 210.08
Molecular Weight: 210.230
Elemental Analysis: C, 74.27; H, 4.79; N, 13.33; O, 7.61
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Synonym: Sibiriline;
IUPAC/Chemical Name: 4-(1H-Pyrrolo[2,3-b]pyridin-2-yl)phenol
InChi Key: XZQLYCMLGSOHOX-UHFFFAOYSA-N
InChi Code: InChI=1S/C13H10N2O/c16-11-5-3-9(4-6-11)12-8-10-2-1-7-14-13(10)15-12/h1-8,16H,(H,14,15)
SMILES Code: OC1=CC=C(C2=CC3=CC=CN=C3N2)C=C1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 210.23 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Le Cann F, Delehouzé C, Leverrier-Penna S, Filliol A, Comte A, Delalande O, Desban N, Baratte B, Gallais I, Piquet-Pellorce C, Faurez F, Bonnet M, Mettey Y, Goekjian P, Samson M, Vandenabeele P, Bach S, Dimanche-Boitrel MT. Sibiriline, a new small chemical inhibitor of receptor-interacting protein kinase 1, prevents immune-dependent hepatitis. FEBS J. 2017 Sep;284(18):3050-3068. doi: 10.1111/febs.14176. Epub 2017 Aug 11. PubMed PMID: 28715128.