WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562134
CAS#: 380877-02-1
Description: MMV-667492 is a potent Ezrin inhibitor.
Hodoodo Cat#: H562134
Name: MMV-667492
CAS#: 380877-02-1
Chemical Formula: C17H19N3O3
Exact Mass: 313.14
Molecular Weight: 313.350
Elemental Analysis: C, 65.16; H, 6.11; N, 13.41; O, 15.32
This product is not in stock, which may be available by custom synthesis.
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Synonym: MMV-667492; MMV 667492; MMV667492;
IUPAC/Chemical Name: N-(3-(Cyclohexylamino)-1,4-dioxo-1,4-dihydronaphthalen-2-yl)-N-methylnitrousamide
InChi Key: QKVXPISYSQXMSA-UHFFFAOYSA-N
InChi Code: InChI=1S/C17H19N3O3/c1-20(19-23)15-14(18-11-7-3-2-4-8-11)16(21)12-9-5-6-10-13(12)17(15)22/h5-6,9-11,18H,2-4,7-8H2,1H3
SMILES Code: O=NN(C(C1=O)=C(NC2CCCCC2)C(C3=C1C=CC=C3)=O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 313.35 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Çelik H, Hong SH, Colón-López DD, Han J, Kont YS, Minas TZ, Swift M, Paige M, Glasgow E, Toretsky JA, Bosch J, Üren A. Identification of Novel Ezrin Inhibitors Targeting Metastatic Osteosarcoma by Screening Open Access Malaria Box. Mol Cancer Ther. 2015 Nov;14(11):2497-507. doi: 10.1158/1535-7163.MCT-15-0511. Epub 2015 Sep 10. PubMed PMID: 26358752; PubMed Central PMCID: PMC4636458.