WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H581082
CAS#: 19379-90-9 (chloride)
Description: Benzoxonium chloride, The topical treatment of anthroponotic cutaneous leishmaniasis with the tincture of thioxolone plus benzoxonium chloride (Thio-Ben) along with cryotherapy. the topical use of Thio-Ben combined with cryotherapy has a good efficacy in treating ACL with the benefit that Thio-Ben has more patient compliance and less side effects than intralesional Glucantime.
Hodoodo Cat#: H581082
Name: Benzoxonium chloride
CAS#: 19379-90-9 (chloride)
Chemical Formula: C23H42ClNO2
Exact Mass: 399.29
Molecular Weight: 400.040
Elemental Analysis: C, 69.06; H, 10.58; Cl, 8.86; N, 3.50; O, 8.00
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Related CAS #: 23884-64-2 (cation) 19379-90-9 (chloride)
Synonym: Benzoxonium chloride; D 301; D301; Cohortan; Bialcol; Bradophen;
IUPAC/Chemical Name: Ammonium, benzylbis(2-hydroxyethyl)dodecyl-, chloride
InChi Key: UUSQFLGKGQEVCM-UHFFFAOYSA-M
InChi Code: InChI=1S/C23H42NO2.ClH/c1-2-3-4-5-6-7-8-9-10-14-17-24(18-20-25,19-21-26)22-23-15-12-11-13-16-23;/h11-13,15-16,25-26H,2-10,14,17-22H2,1H3;1H/q+1;/p-1
SMILES Code: CCCCCCCCCCCC[N+](CCO)(CC1=CC=CC=C1)CCO.[Cl-]
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 400.04 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
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4: Cortat M, Fels P. In vitro activity of benzoxonium chloride on selected buccopharyngeal pathogens. Arzneimittelforschung. 1987 Apr;37(4):463-6. PubMed PMID: 3606701.
5: Finzi GF, Pace M, Grimaldi GP, Perna A, Orlandini L. [Theoretical and experimental considerations on disinfecting substances. Benzoxonium chloride]. Arch Sci Med (Torino). 1982 Jan-Mar;139(1):109-18. Italian. PubMed PMID: 7103699.
6: de Groot AC, Conemans J, Liem DH. Contact allergy to benzoxonium chloride (Bradophen). Contact Dermatitis. 1984 Nov;11(5):324-5. PubMed PMID: 6241131.
7: van Boxtel N, Wolfs K, Palacín MG, Van Schepdael A, Adams E. Headspace gas chromatography based methodology for the analysis of aromatic substituted quaternary ammonium salts. J Chromatogr A. 2016 Dec 9;1476:105-113. doi: 10.1016/j.chroma.2016.11.009. Epub 2016 Nov 9. PubMed PMID: 27884428.
8: Ponzielli G, Taidelli-Palmizi G. [Dodecyl-di-beta-oxyethyl-benzylammonium chloride in the topical therapy of burns]. Clin Ter. 1979 Aug 15;90(3):251-9. Italian. PubMed PMID: 553753.
9: Carpi Torelli P, Tortoli E. [The use of dodecyl-di(beta-oxyethyl) benzylammonium chloride (Bactofen) as a decontaminant in the cultural examination for detection of the Koch bacillus in sputum]. Quad Sclavo Diagn. 1980 Jun;16(2):196-205. Italian. PubMed PMID: 6787655.
10: Kanerva L, Estlander T, Jolanki R. Occupational allergic contact dermatitis from alkylammonium amidobenzoate. Eur J Dermatol. 2001 May-Jun;11(3):240-3. PubMed PMID: 11358732.
11: Riolo U, Pandiani I, Finzi G. [Behavior of disinfectant substances in comparisons of bacterial strains]. Arch Sci Med (Torino). 1982 Oct-Dec;139(4):499-508. Italian. PubMed PMID: 7168641.
12: Tortoli E. [Preliminary evaluations of the use of dodecyl di-(beta-oxyethyl)-benzylammonium chloride as a routine decontaminant for isolation of mycobacteria]. Quad Sclavo Diagn. 1981 Sep;17(3):277-82. Italian. PubMed PMID: 7343980.
13: Auger RR, Potash JB. Delirium from baclofen withdrawal after suicide attempt. Psychosomatics. 2005 Mar-Apr;46(2):151-2. PubMed PMID: 15774955.
14: Saxer UP, Mörmann W, Firestone AR, Eltink B. Plaque control with chlorhexidine and D-301, a quaternary ammonium compound. J Clin Periodontol. 1982 Mar;9(2):162-9. PubMed PMID: 6951841.
15: Hasmann FA, Pessoa A Jr, Roberto IC. beta-Xylosidase recovery by reversed micelles. Use of cationic surfactant. Appl Biochem Biotechnol. 2000 Spring;84-86:1101-11. PubMed PMID: 10849861.
16: Firestone AR, Schmid R, Mühlemann HR. Topical effects of a quaternary ammonium compound on caries incidence and bacterial agglomerate formation in the rat. Caries Res. 1981;15(4):338-40. PubMed PMID: 6940669.
17: Díaz-Ramón L, Aguirre A, Ratón-Nieto JA, de Miguel M. Contact dermatitis from benzoxonium chloride. Contact Dermatitis. 1999 Jul;41(1):53-4. PubMed PMID: 10416720.