WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H562154
CAS#: 1451042-18-4
Description: HDAC3-IN-T247 is a potent and selective HDAC3 inhibitor. It acts by increasing NF-κB acetylation, inducing growth inhibition of cancer cells, and activating HIV gene expression in latent HIV-infected cells.
Hodoodo Cat#: H562154
Name: HDAC3-IN-T247
CAS#: 1451042-18-4
Chemical Formula: C21H19N5OS
Exact Mass: 389.13
Molecular Weight: 389.470
Elemental Analysis: C, 64.76; H, 4.92; N, 17.98; O, 4.11; S, 8.23
Synonym: HDAC3-IN-T247; HDAC3 IN T247; HDAC3INT247; HDAC3 inhibitor T247; HDAC3 inhibitor-T247; T247; T-247; T 247;
IUPAC/Chemical Name: N-(2-Aminophenyl)-4-[1-(2-thiophen-3-ylethyl)-1H-[1],[2],[3]triazol-4-yl]benzamide
InChi Key: LBLSLSOENGWIHL-UHFFFAOYSA-N
InChi Code: InChI=1S/C21H19N5OS/c22-18-3-1-2-4-19(18)23-21(27)17-7-5-16(6-8-17)20-13-26(25-24-20)11-9-15-10-12-28-14-15/h1-8,10,12-14H,9,11,22H2,(H,23,27)
SMILES Code: O=C(NC1=CC=CC=C1N)C2=CC=C(C3=CN(CCC4=CSC=C4)N=N3)C=C2
Appearance: Solid powder
Purity: >95% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934994400
More Info:
Biological target: | |
In vitro activity: | |
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The following data is based on the product molecular weight 389.47 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Suzuki T, Kasuya Y, Itoh Y, Ota Y, Zhan P, Asamitsu K, Nakagawa H, Okamoto T, Miyata N. Identification of highly selective and potent histone deacetylase 3 inhibitors using click chemistry-based combinatorial fragment assembly. PLoS One. 2013 Jul 16;8(7):e68669. doi: 10.1371/journal.pone.0068669. Print 2013. PubMed PMID: 23874714; PubMed Central PMCID: PMC3713009.