SCH-336
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Hodoodo CAT#: H555160

CAS#: 447459-51-0

Description: SCH-336 is a potent and selective CB2 inverse agonist. Sch.336 is an inverse agonist at hCB(2), as shown by its ability to decrease guanosine 5'-3-O-(thio)triphosphate (GTPgammaS) binding to membranes containing hCB(2), by the ability of GTPgammaS to left-shift Sch.336 binding to hCB(2) in these membranes, and by the compound's ability to increase forskolin-stimulated cAMP levels in CHO cells expressing hCB(2).

Chemical Structure

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SCH-336
CAS# 447459-51-0
Instruction

Theoretical Analysis

Hodoodo Cat#: H555160
Name: SCH-336
CAS#: 447459-51-0
Chemical Formula: C23H25NO8S3
Exact Mass: 539.07
Molecular Weight: 539.632
Elemental Analysis: C, 51.19; H, 4.67; N, 2.60; O, 23.72; S, 17.82

Price and Availability

Size Price Availability Quantity
25mg USD 450 2 Weeks
50mg USD 750 2 Weeks
100mg USD 1350 2 Weeks
200mg USD 2350 2 Weeks
1g USD 4250 2 Weeks
Bulk inquiry

Synonym: SCH-336; SCH 336; SCH336.

IUPAC/Chemical Name: N-[(1S)-1-[4-[[4-Methoxy-2-[(4-methoxyphenyl)sulfonyl]phenyl]sulfonyl]phenyl]ethyl]methanesulfonamide

InChi Key: NXODIUKWAVUFGF-INIZCTEOSA-N

InChi Code: InChI=1S/C23H25NO8S3/c1-16(24-33(4,25)26)17-5-10-20(11-6-17)34(27,28)22-14-9-19(32-3)15-23(22)35(29,30)21-12-7-18(31-2)8-13-21/h5-16,24H,1-4H3/t16-/m0/s1

SMILES Code: CS(=O)(N[C@H](C1=CC=C(S(=O)(C2=CC=C(OC)C=C2S(=O)(C3=CC=C(OC)C=C3)=O)=O)C=C1)C)=O

Appearance: Solid powder

Purity: >98% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 539.63 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Lunn CA, Fine JS, Rojas-Triana A, Jackson JV, Fan X, Kung TT, Gonsiorek W,
Schwarz MA, Lavey B, Kozlowski JA, Narula SK, Lundell DJ, Hipkin RW, Bober LA. A
novel cannabinoid peripheral cannabinoid receptor-selective inverse agonist
blocks leukocyte recruitment in vivo. J Pharmacol Exp Ther. 2006
Feb;316(2):780-8. Epub 2005 Oct 28. PubMed PMID: 16258021.