WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H584345
CAS#: 393856-87-6
Description: KP-544 is a neurotrophin potentiator.
Hodoodo Cat#: H584345
Name: KP-544
CAS#: 393856-87-6
Chemical Formula: C18H19ClN4O
Exact Mass: 342.12
Molecular Weight: 342.827
Elemental Analysis: C, 63.06; H, 5.59; Cl, 10.34; N, 16.34; O, 4.67
This product is not in stock, which may be available by custom synthesis.
For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge).
Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.
Synonym: KP-544; KP544; KP 544
IUPAC/Chemical Name: 2-Amino-5-(4-chlorophenylethynyl)-4-(trans-4-hydroxycyclohexylamino)pyrimidine
InChi Key: XBVOXAWRUIZEMG-WKILWMFISA-N
InChi Code: InChI=1S/C18H19ClN4O/c19-14-5-2-12(3-6-14)1-4-13-11-21-18(20)23-17(13)22-15-7-9-16(24)10-8-15/h2-3,5-6,11,15-16,24H,7-10H2,(H3,20,21,22,23)/t15-,16-
SMILES Code: O[C@H]1CC[C@H](NC2=NC(N)=NC=C2C#CC3=CC=C(Cl)C=C3)CC1
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
Biological target: | |
In vitro activity: | |
In vivo activity: |
The following data is based on the product molecular weight 342.83 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
Formulation protocol: | |
In vitro protocol: | |
In vivo protocol: |
1: Dey ND, Boersen AJ, Myers RA, York LR, Bombard MC, Lu M, Sandstrom MI, Hulce VD, Lescaudron L, Dunbar GL. The novel substituted pyrimidine, KP544, reduces motor deficits in the R6/2 transgenic mouse model of Huntington's disease. Restor Neurol Neurosci. 2007;25(5-6):485-92. PubMed PMID: 18334766.
2: Geist MA, Volbracht C, Podhorna J, Falsig J, Leist M. Wide spectrum modulation by KP-544 in models relevant for neuronal survival. Neuroreport. 2007 Apr 16;18(6):571-5. PubMed PMID: 17413659.