WARNING: This product is for research use only, not for human or veterinary use.
Hodoodo CAT#: H341064
CAS#: 70386-06-0
Description: Y590 is a PDE3 inhibitor. Y-590 incubated with washed rabbit platelets did not affect the cyclic AMP (cAMP) content. But when added to the washed platelets 1.5 minutes before prostaglandin I2 (PGI2), it potentiated the ability of the latter to increase cAMP. Y-590 potently inhibited cAMP-PDE in rabbit platelets, but its inhibitory effect on cGMP-PDE was less potent. Its G/A (IC50 for cGMP-PDE/IC50 for cAMP-PDE) was 1055, about 60 times that of papaverine. The concentration of Y-590 causing inhibition of cAMP-PDE was the same degree as that inhibiting platelet aggregation. Y-590 is a selective inhibitor of cAMP-PDE which exerts its anti-platelet activity by inhibiting cAMP degradation in platelets.
Hodoodo Cat#: H341064
Name: Y 590
CAS#: 70386-06-0
Chemical Formula: C15H17N3O2
Exact Mass: 271.13
Molecular Weight: 271.320
Elemental Analysis: C, 66.40; H, 6.32; N, 15.49; O, 11.79
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Synonym: Y 590; Y-590; Y590
IUPAC/Chemical Name: 2(1H)-Quinolinone, 3,4-dihydro-1-methyl-6-(1,4,5,6-tetrahydro-4-methyl-6-oxo-3-pyridazinyl)-
InChi Key: JHPWSIOCWUJGJE-SECBINFHSA-N
InChi Code: InChI=1S/C15H17N3O2/c1-9-7-13(19)16-17-15(9)11-3-5-12-10(8-11)4-6-14(20)18(12)2/h3,5,8-9H,4,6-7H2,1-2H3,(H,16,19)/t9-/m1/s1
SMILES Code: N1(C(CCc2cc(ccc12)C=1[C@@H](CC(NN1)=O)C)=O)C
Appearance: Solid powder
Purity: >98% (or refer to the Certificate of Analysis)
Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.
Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Solubility: Soluble in DMSO
Shelf Life: >2 years if stored properly
Drug Formulation: This drug may be formulated in DMSO
Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).
HS Tariff Code: 2934.99.9001
More Info:
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The following data is based on the product molecular weight 271.32 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.15 mL | 5.76 mL | 11.51 mL |
| 5 mM | 0.23 mL | 1.15 mL | 2.3 mL |
| 10 mM | 0.12 mL | 0.58 mL | 1.15 mL |
| 50 mM | 0.02 mL | 0.12 mL | 0.23 mL |
| Formulation protocol: | |
| In vitro protocol: | |
| In vivo protocol: |
1: Yao J, Zhang Y, Zhang J, Yang X. [Effect of Lactobacillus acidophilus on metabolizing lactic acid in formula milk: a quantitative analysis of the effect of erythritol]. Zhonghua Kou Qiang Yi Xue Za Zhi. 2015 Jul;50(7):408-12. Chinese. PubMed PMID: 26564744.
2: Zavala G, Pretto C, Chow YH, Jones L, Alberti A, Grego E, De las Heras M, Palmarini M. Relevance of Akt phosphorylation in cell transformation induced by Jaagsiekte sheep retrovirus. Virology. 2003 Jul 20;312(1):95-105. PubMed PMID: 12890624.
3: Ohno Y, Ishida H, Hayashi A, Kamagata S, Hirobe S, Ishii K. The mean transit time and functional image in asialoglycoprotein receptor scintigraphy: a novel modality for evaluating the regional dynamic function of hepatocytes. J Nucl Med. 2002 Dec;43(12):1611-5. PubMed PMID: 12468509.
4: Combs DW, Rampulla MS, Demers JP, Falotico R, Moore JB. Heteroatom analogues of bemoradan: chemistry and cardiotonic activity of 1,4-benzothiazinylpyridazinones. J Med Chem. 1992 Jan;35(1):172-6. PubMed PMID: 1732525.
5: Mikashima H, Nakao T, Goto K, Ochi H, Yasuda H, Tsumagari T. Y-590 (a new pyridazinone derivative), a potent anti-thrombotic agent--II. Inhibition of platelet phosphodiesterase. Thromb Res. 1984 Sep 1;35(5):589-94. PubMed PMID: 6091293.
