EPZ-025654 HCl

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Hodoodo CAT#: H562179

CAS#: EPZ-025654 HCl

Description: EPZ-025654 is a potent and selective arginine methyltransferase CARM1 inhibitor.


Chemical Structure

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EPZ-025654 HCl
CAS# EPZ-025654 HCl

Theoretical Analysis

Hodoodo Cat#: H562179
Name: EPZ-025654 HCl
CAS#: EPZ-025654 HCl
Chemical Formula: C29H34Cl2N8O3
Exact Mass: 576.24
Molecular Weight: 613.544
Elemental Analysis: C, 56.77; H, 5.59; Cl, 11.56; N, 18.26; O, 7.82

Price and Availability

This product is not in stock, which may be available by custom synthesis. For cost-effective reason, minimum order is 1g (price is usually high, lead time is 2~3 months, depending on the technical challenge). Quote less than 1g will not be provided. To request quote, please email to sales @hodoodo.com or click below button.
Note: Price will be listed if it is available in the future.

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Related CAS #: 1888328-89-9 (free base)   EPZ-025654 HCl    

Synonym: EPZ-025654; EPZ 025654; EPZ025654; GSK35336023; GSK-35336023; GSK 35336023; EPZ-025654 HCl; EPZ-025654 hydrochloride

IUPAC/Chemical Name: (R)-1-(3-(4-(2-(Azetidin-1-yl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-6-(3,5-dimethylisoxazol-4-yl)-5-methylpyrimidin-2-yl)-4-chlorophenoxy)-3-(methylamino)propan-2-ol hydrochloride

InChi Key: FJRSBGGFLPVXPH-HXUWFJFHSA-N

InChi Code: InChI=1S/C29H33ClN8O3/c1-16-26(25-17(2)36-41-18(25)3)34-27(22-10-21(6-7-23(22)30)40-15-20(39)12-31-4)35-28(16)38-13-19-11-32-29(33-24(19)14-38)37-8-5-9-37/h6-7,10-11,20,31,39H,5,8-9,12-15H2,1-4H3/t20-/m1/s1

SMILES Code: O[C@H](CNC)COC1=CC=C(Cl)C(C2=NC(C3=C(C)ON=C3C)=C(C)C(N4CC5=NC(N6CCC6)=NC=C5C4)=N2)=C1

Appearance: Solid powder

Purity: >97% (or refer to the Certificate of Analysis)

Shipping Condition: Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs.

Storage Condition: Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).

Solubility: Soluble in DMSO

Shelf Life: >2 years if stored properly

Drug Formulation: This drug may be formulated in DMSO

Stock Solution Storage: 0 - 4 C for short term (days to weeks), or -20 C for long term (months).

HS Tariff Code: 2934.99.9001

More Info:

Biological target:
In vitro activity:
In vivo activity:

Preparing Stock Solutions

The following data is based on the product molecular weight 613.54 Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Recalculate based on batch purity %
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 1.15 mL 5.76 mL 11.51 mL
5 mM 0.23 mL 1.15 mL 2.3 mL
10 mM 0.12 mL 0.58 mL 1.15 mL
50 mM 0.02 mL 0.12 mL 0.23 mL
Formulation protocol:
In vitro protocol:
In vivo protocol:

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1: Drew AE, Moradei O, Jacques SL, Rioux N, Boriack-Sjodin AP, Allain C, Scott MP, Jin L, Raimondi A, Handler JL, Ott HM, Kruger RG, McCabe MT, Sneeringer C, Riera T, Shapiro G, Waters NJ, Mitchell LH, Duncan KW, Moyer MP, Copeland RA, Smith J, Chesworth R, Ribich SA. Identification of a CARM1 Inhibitor with Potent In Vitro and In Vivo Activity in Preclinical Models of Multiple Myeloma. Sci Rep. 2017 Dec 21;7(1):17993. doi: 10.1038/s41598-017-18446-z. PubMed PMID: 29269946; PubMed Central PMCID: PMC5740082.